ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Operationalizing the centiloid scale for [
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 18 citations in OpenAlex.
- MIND diet-related plasma proteins are associated with Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebellar cortical amyloid deposition biasesEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Plasma proteomic Alzheimer's risk score: Biological age clock and pseudotime trajectory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging.Neurology · 2025Article
- Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.Brain : a journal of neurology · 2025Article
- Establishing Regional Aβ Cutoffs and Exploring Subgroup Prevalence Across Cognitive Stages Using BeauBrain AmyloDementia and neurocognitive disorders · 2025Article
- Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Digital detector PET/CT increases Centiloid measures of amyloid in Alzheimer's disease: A head-to-head comparison of cameras.Journal of Alzheimer's disease : JAD · 2025Article
- The relationship between leisure time physical activity patterns, Alzheimer's disease markers and cognition.Brain communications · 2025Article
- Associations between night/shift working and late-life brain health.Brain communications · 2025Article
- Impact of shortening time on diagnosis ofEJNMMI research · 2024Article
- Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging.Diagnostics (Basel, Switzerland) · 2024Review
- A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2024Review
- Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds.Brain communications · 2023Article
- Inter-software variability of Centiloid quantification in amyloid PET: A head-to-head comparison of five software platforms.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Operationalizing the centiloid scale for [Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
26 authors at 9 institutions in 3 countries.
Funding
Abstract
introductionThe Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI).
methodsWe transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling-derived cutpoints for Aβ PET positivity were converted.
resultsThe Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM-based Centiloids. Linear adjustment produced a WM-based cutpoint of 18.1. DISCUSSION: Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed. HIGHLIGHTS: Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.Centiloid values can be influenced by differences in acquisition.We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.Whole cerebellum referenced values could be reliably transformed to Centiloids.White matter referenced values may be less generalizable between datasets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.