Evidence map›Paper›PMID 37200803›Full record

ArticleACS pharmacology & translational science2023

Multitargeted 6-Substituted Thieno[2,3-

Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C Nyman, Jade M Katinas, Mathew Schneider, Carrie O'Connor, Xun Bao, Seongho Kim and 5 more

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Duplicate entries in the Protein Data Bank: how to detect and handle them.Acta crystallographica. Section D, Structural biology · 2025
    Article
  2. A journey into the regulatory secrets of theFrontiers in pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nian TongDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0000-0002-2934-999X
Jennifer Wong-RousharDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Adrianne Wallace-PovirkDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Yesha ShahDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0009-0000-5271-5567
Morgan C NymanDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Jade M KatinasDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Mathew SchneiderDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Carrie O'ConnorDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Xun BaoBarbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
Seongho KimDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Jing LiDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Zhanjun HouDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Larry H MatherlyDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Charles E DannDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Aleem GangjeeDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0000-0002-5513-7616

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
MOLECULAR REGULATION OF FOLATE AND ANTIFOLATE TRANSPORTR01CA053535 · NCI · WAYNE STATE UNIVERSITY · PI HOU, ZHANJUN, MATHERLY, LARRY H · 1993 to 2024
$6.3M
TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3M
Therapeutic Targeting Mitochondrial C1 MetabolismR01CA250469 · NCI · WAYNE STATE UNIVERSITY · PI DANN, CHARLES E., GANGJEE, ALEEM · 2021 to 2025
$3.0M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
Purine Synthesis Inhibitors with Selective Folate Receptor Tumor TransportR01CA166711 · NCI · DUQUESNE UNIVERSITY · PI DANN, CHARLES E., GANGJEE, ALEEM · 2013 to 2015
$1.7M
Targeting Mitochondrial One-Carbon Metabolism in Epithelial Ovarian CancerF31CA243215 · NCI · WAYNE STATE UNIVERSITY · PI WALLACE-POVIRK, ADRIANNE · 2019 to 2020
$85k
NCI NIH HHS F31 CA243215NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA053535NCI NIH HHS R01 CA166711NCI NIH HHS R01 CA250469NCI NIH HHS T32 CA009531NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P41 GM103311NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

Multitargeted agents with tumor selectivity result in reduced drug resistance and dose-limiting toxicities. We report 6-substituted thieno[2,3-

Identifiers

PMID37200803
PMCPMC10186366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.