ArticleClinical & experimental metastasis
The invasive edge: invasion in colorectal cancer.
Article in Clinical & experimental metastasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- CGREF1 promotes cancer cell migration and predicts poor prognosis in colorectal cancer.Journal of cancer research and clinical oncology · 2025Article
- Application of Modified ITBCC Criteria of Tumor Budding in Oral Squamous Cell Carcinoma and its Correlation with Clinicopathological Parameters and Overall Survival.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Establishment of a tissue-engineered colon cancer model for comparative analysis of cancer cell lines.Journal of biomedical materials research. Part A · 2024Article
- Tumour budding and poorly differentiated clusters in colon cancer - different manifestations of partial epithelial-mesenchymal transition.The Journal of pathology · 2022Article
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- Modes of invasion during tumour dissemination.Molecular oncology · 2017Review
- Tumor Budding: The Name is EMT. Partial EMT.Journal of clinical medicine · 2016Review
- Clinical significance of extrabowel skipped cancer infiltration in rectal cancer.Surgery today · 1997Article
- The role of fibroblasts in tumor behavior.Cancer metastasis reviews · 1995Review
- The clinical significance of regional variations in histologic differentiation within carcinomas of the colorectum.Surgery today · 1993Article
- Modulation of invasive potential in different clonal subpopulations of a rat rhabdomyosarcoma cell line (BA-HAN-1) by differentiation induction.Clinical & experimental metastasis · 1993Article
- Neoplastic invasion in experimental carcinoma of the colon: abnormal differentiation and release of mucus.Clinical & experimental metastasisArticle
- A morphometric study of invasion and metastasis in human colorectal carcinoma.Clinical & experimental metastasisArticle
- Mechanisms of invasion and lymphatic penetration in human colorectal cancer.Clinical & experimental metastasisArticle
- Morphogenesis as a parallel of invasion: the epithelial-mesenchymal boundary and basal lamina in foetal rat colon.Clinical & experimental metastasisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary human colorectal carcinomas which had already metastasized to the draining lymph nodes have been studied by transmission electron microscopy and tissue culture. The invasive edges were identified by examining mirror-image blocks for light and electron microscopy. In the invasive edge there are single cells and small clusters of cells which have ultrastructural features suggestive of active cell movement; clusters of cells are found in the lymphatic trunks and in the subcapsular sinus of draining lymph nodes. Small clusters of cells survive in short-term culture; some of these cells are actively motile. These findings support the view that there is a sub-population of motile and invasive cells at the edge of human colorectal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.