Evidence map›Paper›PMID 37200453›Full record

ArticleJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2023

Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent.

Uttio Roy Chowdhury, Cynthia L Pervan-Steel, Ryan Sheeler, Hemchand K Sookdeo, Brian Rogers, Ralph Casale, Peter I Dosa, Thurein Htoo, Barbara M Wirostko, Michael P Fautsch

Open access · greenAbstract read
In one paragraph

Article in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Uttio Roy ChowdhuryDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Cynthia L Pervan-SteelQlaris Bio, Inc., Dedham, Massachusetts, USA.
Ryan SheelerNorthEast BioLab, Hamden, Connecticut, USA.
Hemchand K SookdeoQlaris Bio, Inc., Dedham, Massachusetts, USA.
Brian RogersPacific BioDevelopment, LLC, Emeryville, California, USA.
Ralph CasaleQlaris Bio, Inc., Dedham, Massachusetts, USA.
Peter I DosaInstitute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
Thurein HtooQlaris Bio, Inc., Dedham, Massachusetts, USA.
Barbara M WirostkoQlaris Bio, Inc., Dedham, Massachusetts, USA.
Michael P FautschDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9115-2485
Entegris (United States) · USMayo Clinic · USUniversity of Minnesota · USUniversidad Del Pacifico · CO

Funding

Intraocular pressure regulation via ATP-sensitive potassium channelsR01EY021727 · NEI · MAYO CLINIC ROCHESTER · PI FAUTSCH, MICHAEL P. · 2011 to 2021
$4.1M
NEI NIH HHS R01 EY021727
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ProdrugsAdministration, TopicalAnimalsAntihypertensive AgentsChromatography, LiquidCorneaCromakalimDogsOphthalmic SolutionsRabbitsTandem Mass SpectrometryAntihypertensive AgentsCromakalimOphthalmic SolutionsProdrugsATP-sensitive potassium channelCKLP1glaucomaintraocular pressurelevcromakalimprodrug

Identifiers

PMID37200453
PMCPMC10398739
OpenAlexW4377014287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.