Evidence map›Paper›PMID 37200427›Full record

ArticleScience (New York, N.Y.)2023

Generality-oriented optimization of enantioselective aminoxyl radical catalysis.

Jonas Rein, Soren D Rozema, Olivia C Langner, Samson B Zacate, Melissa A Hardy, Juno C Siu, Brandon Q Mercado, Matthew S Sigman, Scott J Miller, Song Lin

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Heterogeneous Indirect Redox Electrocatalysis in Electrolyte.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals.Journal of the American Chemical Society · 2026
    Article
  8. Article
  9. Article
  10. Desymmetrization ofJournal of the American Chemical Society · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Considerations in Pursuing Reaction Scope Generality.Angewandte Chemie (International ed. in English) · 2025
    Review
  15. Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025
    Review
  16. Article
  17. Privileged Chiral Photocatalysts.Angewandte Chemie (International ed. in English) · 2025
    Review
  18. Automated Iterative N─C and C─C Bond Formation.Angewandte Chemie (International ed. in English) · 2025
    Article
  19. Article
  20. Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonas Rein *Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-8237-6519
Soren D Rozema *Department of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-3415-676X
Olivia C Langner *Department of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-1875-8173
Samson B Zacate *Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3882-3785
Melissa A HardyDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3924-4518
Juno C SiuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Brandon Q MercadoDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-1940-3497
Matthew S SigmanDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-5746-8830
Scott J MillerDepartment of Chemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-7817-1318
Song LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-8880-6476

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
Data Science Guided Organic Reaction DevelopmentR35GM136271 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MATTHEW S SIGMAN · 2020 to 2026
$3.5M
Radical redox catalysis by Ti complexesR01GM134088 · NIGMS · STANFORD UNIVERSITY · PI Song Lin · 2020 to 2026
$2.4M
NIGMS NIH HHS R01 GM134088NIGMS NIH HHS R35 GM132092NIGMS NIH HHS R35 GM136271
6 · The paper itself

Abstract

Catalytic enantioselective methods that are generally applicable to a broad range of substrates are rare. We report a strategy for the oxidative desymmetrization of

Identifiers

PMID37200427
PMCPMC10277815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.