Evidence map›Paper›PMID 37199965›Full record

ArticlePsychology and aging2023

Semantic item-level metrics relate to future memory decline beyond existing cognitive tests in older adults without dementia.

Jet M J Vonk, Mirjam I Geerlings, Justina F Avila-Rieger, Carolyn L Qian, Nicole Schupf, Richard Mayeux, Adam M Brickman, Jennifer J Manly

Open access · hybridAbstract read
In one paragraph

Article in Psychology and aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Distinguishable features of spontaneous speech in Alzheimer's clinical syndrome and healthy controls.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jet M J VonkDepartment of Neurology, Memory and Aging Center, University of California San Francisco.ORCID 0000-0002-1808-8843
Mirjam I GeerlingsDepartment of General Practice, Amsterdam University Medical Centers, University of Amsterdam.
Justina F Avila-RiegerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Carolyn L QianTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University.
Columbia University · USUniversity of California, San Francisco · USUtrecht University · NL

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Preclinical markers of Alzheimer's disease using psycholinguistic semantic measuresR00AG066934 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONK, JET M.J. · 2022 to 2024
$1.2M
NCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS R00 AG066934NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG072474NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

In normal aging, the cognitive domain of semantic memory remains preserved, while the domain of episodic memory declines to some extent. In Alzheimer's disease dementia, both semantic and episodic memory become impaired early in the disease process. Given the need to develop sensitive and accessible cognitive markers for early detection of dementia, we investigated among older adults without dementia whether item-level metrics of semantic fluency related to episodic memory decline above and beyond existing neuropsychological measures and total fluency score. Participants were drawn from the community-based Washington Heights-Inwood Columbia Aging Project cohort (

Indexed as

Alzheimer DiseaseCognitive DysfunctionMemory, EpisodicAgedAged, 80 and overAgingHumansMemory DisordersNeuropsychological TestsSemantics

Identifiers

PMID37199965
PMCPMC10440298
OpenAlexW4377010564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.