Evidence map›Paper›PMID 37199916›Full record

ArticleAmerican journal of physiology. Renal physiology2023

The mast cell stimulator compound 48/80 causes urothelium-dependent increases in murine urinary bladder contractility.

B Malique Jones, Gerald C Mingin, Nathan R Tykocki

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

B Malique JonesDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States.ORCID 0000-0002-6614-9962
Gerald C MinginLarner College of Medicine, University of Vermont, Burlington, Vermont, United States.
Nathan R TykockiDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States.ORCID 0000-0001-5432-7656
Michigan United · USUniversity of Vermont · US

Funding

TRPV1 Mediates Progressive Stress-Induced Bladder DysfunctionR01DK119615 · NIDDK · MICHIGAN STATE UNIVERSITY · PI MINGIN, GERALD, TYKOCKI, NATHAN ROGER · 2019 to 2023
$1.9M
MI-CURE Research ProjectP20DK127554 · NIDDK · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI ZWAANS, BERNADETTE MARGARETHA MARIA · 2021 to 2022
$621k
NIDDK NIH HHS P20 DK127554NIDDK NIH HHS R01 DK119615
6 · The paper itself

Abstract

Mast cells and degranulation of preformed inflammatory mediators contribute to lower urinary tract symptoms. This study investigated pathways by which the mast cell stimulator compound 48/80 alters urinary bladder smooth muscle contractility via mast cell activation. We hypothesized that

Indexed as

Mast CellsUrinary BladderAnimalsMiceMuscle ContractionMuscle, SmoothUrotheliummast cellsprostaglandinsurinary bladderurothelium

Identifiers

PMID37199916
PMCPMC10292985
OpenAlexW4377010884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.