Evidence map›Paper›PMID 37199648›Full record

ArticleJournal of virology2023

Influenza C and D Viruses Demonstrated a Differential Respiratory Tissue Tropism in a Comparative Pathogenesis Study in Guinea Pigs.

Chithra C Sreenivasan, Runxia Liu, Rongyuan Gao, Yicheng Guo, Ben M Hause, Milton Thomas, Ahsan Naveed, Travis Clement, Dana Rausch, Jane Christopher-Hennings and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Influenza C virus in humans and animals.Clinical and experimental vaccine research · 2025
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Chithra C SreenivasanDepartment of Veterinary Science, M. H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA.
Runxia LiuDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Rongyuan GaoDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Yicheng GuoZuckerman Mind Brian Behavior Institute, Columbia University, New York, New York, USA.
Ben M HauseDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.ORCID 0000-0003-2463-4676
Milton ThomasDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Ahsan NaveedDepartment of Veterinary Science, M. H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA.
Travis ClementDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Dana RauschDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Jane Christopher-HenningsDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Eric NelsonDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA.
Julian DruceVirology Section, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia.
Miaoyun ZhaoNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Radhey S KaushikDepartment of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, USA.
Qingsheng LiNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0003-4101-4073
Zizhang ShengZuckerman Mind Brian Behavior Institute, Columbia University, New York, New York, USA.
Dan WangDepartment of Veterinary Science, M. H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA.
Feng LiDepartment of Veterinary Science, M. H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-8904-2893
South Dakota State University · USUniversity of Kentucky · USColumbia University · USUniversity of Nebraska–Lincoln · USVictorian Infectious Diseases Reference Laboratory · AU

Funding

Influenza D Virus Entry and Tissue TropismR01AI141889 · NIAID · UNIVERSITY OF KENTUCKY · PI LI, FENG · 2018 to 2022
$2.6M
NIAID NIH HHS R01 AI141889
6 · The paper itself

Abstract

Influenza C virus (ICV) is increasingly associated with community-acquired pneumonia (CAP) in children and its disease severity is worse than the influenza B virus, but similar to influenza A virus associated CAP. Despite the ubiquitous infection landscape of ICV in humans, little is known about its replication and pathobiology in animals. The goal of this study was to understand the replication kinetics, tissue tropism, and pathogenesis of human ICV (huICV) in comparison to the swine influenza D virus (swIDV) in guinea pigs. Intranasal inoculation of both viruses did not cause clinical signs, however, the infected animals shed virus in nasal washes. The huICV replicated in the nasal turbinates, soft palate, and trachea but not in the lungs while swIDV replicated in all four tissues. A comparative analysis of tropism and pathogenesis of these two related seven-segmented influenza viruses revealed that swIDV-infected animals exhibited broad tissue tropism with an increased rate of shedding on 3, 5, and 7 dpi and high viral loads in the lungs compared to huICV. Seroconversion occurred late in the huICV group at 14 dpi, while swIDV-infected animals seroconverted at 7 dpi. Guinea pigs infected with huICV exhibited mild to moderate inflammatory changes in the epithelium of the soft palate and trachea, along with mucosal damage and multifocal alveolitis in the lungs. In summary, the replication kinetics and pathobiological characteristics of ICV in guinea pigs agree with the clinical manifestation of ICV infection in humans, and hence guinea pigs could be used to study these distantly related influenza viruses.

Indexed as

Disease Models, AnimalGammainfluenzavirusGuinea PigsOrthomyxoviridae InfectionsThogotovirusAdministration, IntranasalAnimalsHumansReceptors, VirusReceptors, Virusanimal modelsGuinea pigsinfluenzaInfluenza CInfluenza Din vivopathogenesisTissue tropismvirulence

Identifiers

PMID37199648
PMCPMC10308911
OpenAlexW4377011405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.