Evidence map›Paper›PMID 37199627›Full record

ArticleJournal of virology2023

Viral Capsid, Antibody, and Receptor Interactions: Experimental Analysis of the Antibody Escape Evolution of Canine Parvovirus.

Robert A López-Astacio, Oluwafemi F Adu, Daniel J Goetschius, Hyunwook Lee, Wendy S Weichert, Brian R Wasik, Simon P Frueh, Brynn K Alford, Ian E H Voorhees, Joseph F Flint and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Impact of VP2 mutations on viral fitness in canine parvovirus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  2. Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Structures and functions of the limited natural polyclonal antibody response to parvovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Robert A López-AstacioJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-9049-7764
Oluwafemi F AduJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Daniel J GoetschiusDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, USA.
Hyunwook LeeDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, USA.
Wendy S WeichertJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Brian R WasikJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-5442-3883
Simon P FruehJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Brynn K AlfordJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Ian E H VoorheesJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Joseph F FlintJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Sarah SaddorisJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Laura B GoodmanJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-8327-3092
Edward C HolmesSydney Institute for Infectious Diseases, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9596-3552
Susan L HafensteinDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, USA.
Colin R ParrishJames A. Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0002-1836-6655
Cornell University · USPennsylvania State University · USThe University of Sydney · AU

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
The Evolutionary and Biological Bases of Host Switching in VirusesR01GM080533 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PARRISH, COLIN R. · 2007 to 2019
$4.1M
Structural Controls of Functional Receptor and Antibody Binding to Viral Capsids.R01AI092571 · NIAID · CORNELL UNIVERSITY · PI PARRISH, COLIN R. · 2011 to 2021
$4.0M
NIAID NIH HHS R01 AI092571NIGMS NIH HHS R01 GM080533NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Canine parvovirus (CPV) is a small nonenveloped single-stranded DNA virus that causes serious diseases in dogs worldwide. The original strain of the virus (CPV-2) emerged in dogs during the late 1970s due to a host range switch of a virus similar to the feline panleukopenia virus that infected another host. The virus that emerged in dogs had altered capsid receptor and antibody binding sites, with some changes affecting both functions. Further receptor and antibody binding changes arose when the virus became better adapted to dogs or to other hosts. Here, we used

Indexed as

Antibodies, ViralBinding Sites, AntibodyCapsidParvovirus, CanineAnimalsAntigens, ViralCapsid ProteinsDogsEpitopesHigh-Throughput Nucleotide SequencingMutationSelection, GeneticAntibodies, ViralAntigens, ViralCapsid ProteinsEpitopesantibodiescapsidevolutionimmune escapemutationsparvovirusselection

Identifiers

PMID37199627
PMCPMC10308881
OpenAlexW4377010929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.