Evidence map›Paper›PMID 37199336›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Pragmatic approaches to handling practice effects in longitudinal cognitive aging research.

Ruijia Chen, Camilla Calmasini, Kaitlin Swinnerton, Jingxuan Wang, Sebastien Haneuse, Sarah F Ackley, Andrew K Hirst, Eleanor Hayes-Larson, Kristen M George, Rachel Peterson and 8 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. Social network characteristics and cognitive function, decline, and mortality: A joint modeling approach.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  14. Association of Depression Dimensions With Cognitive Functioning in Community-Dwelling Oldest-Old Adults: The LifeAfter90 Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  15. Childhood adversity and late-life cognitive and brain health in a diverse cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  16. Addressing Practice Effects in Population-Based Studies of Trends in Late-Life Dementia and Cognitive Impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  17. Dementia Prevalence, Incidence, and Mortality Trends Among U.S. Adults Ages 72 and Older, 2011-2021.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Ruijia ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Camilla CalmasiniDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Kaitlin SwinnertonDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Jingxuan WangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Sebastien HaneuseDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Sarah F AckleyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Andrew K HirstDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Eleanor Hayes-LarsonDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Kristen M GeorgeDepartment of Public Health Sciences, University of California, Davis, California, USA.
Rachel PetersonSchool of Public Health and Community Health Sciences, University of Montana, Missoula, Montana, USA.
Yenee SohDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Lisa L BarnesDepartment of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Medical College, Chicago, Illinois, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Dan M MungasDepartment of Neurology, University of California, Davis, California, USA.
Rachel A WhitmerDepartment of Public Health Sciences, University of California, Davis, California, USA.
Maria M CorradaDepartment of Neurology, University of California, Irvine, California, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
University of California, San Francisco · USKaiser Permanente · USUniversity of California, Davis · USFielding Graduate University · USHarvard University · USRush University Medical Center · USUniversity of California, Irvine · USUniversity of Montana · US

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Audrey Peiwen Fan · 2021 to 2026
$25.2M
Study of Healthy Aging in African AmericansR01AG050782 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Paola Gilsanz, Rachel A Whitmer · 2023 to 2026
$19.1M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Early Vascular Contributions to Dementia Risk in African-AmericansRF1AG050782 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WHITMER, RACHEL A · 2017 to 2017
$3.8M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related DementiasR00AG073457 · NIA · UNIVERSITY OF MONTANA · PI PETERSON, RACHEL LYNNE · 2022 to 2024
$724k
Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep DisturbanceK00AG068431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, RUIJIA · 2021 to 2024
$330k
Mathematical Models of Tau-PET Measures and Cognitive Decline in Alzheimer’s Disease Across the LifespanK99AG073454 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ACKLEY, SARAH · 2022 to 2024
$250k
Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkersK99AG075317 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAYES-LARSON, ELEANOR LOUISE · 2022 to 2023
$241k
C ELEGANS LIFE SPAN--DAUER AND DROSOPHILA MRNA MARKERSF32AG005651 · NIA · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · PI THADEN, JOHN J · 1994 to 1995
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NIA NIH HHS F32 AG005651NIA NIH HHS K00 AG068431NIA NIH HHS K99 AG073454NIA NIH HHS K99 AG075317NIA NIH HHS P30 AG072972NIA NIH HHS R00 AG073457NIA NIH HHS R01 AG050782NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG056519NIA NIH HHS R01 AG066132NIA NIH HHS RF1 AG050782
6 · The paper itself

Abstract

introductionThe challenge of accounting for practice effects (PEs) when modeling cognitive change was amplified by the COVID-19 pandemic, which introduced period and mode effects that may bias the estimation of cognitive trajectory.

methodsIn three Kaiser Permanente Northern California prospective cohorts, we compared predicted cognitive trajectories and the association of grip strength with cognitive decline using three approaches: (1) no acknowledgment of PE, (2) inclusion of a wave indicator, and (3) constraining PE based on a preliminary model (APM) fit using a subset of the data.

resultsAPM-based correction for PEs based on balanced, pre-pandemic data, and with current age as the timescale produced the smallest discrepancy between within-person and between-person estimated age effects. Estimated associations between grip strength and cognitive decline were not sensitive to the approach used. DISCUSSION: Constraining PEs based on a preliminary model is a flexible, pragmatic approach allowing for meaningful interpretation of cognitive change. HIGHLIGHTS: The magnitude of practice effects (PEs) varied widely by study. When PEs were present, the three PE approaches resulted in divergent estimated age-related cognitive trajectories. Estimated age-related cognitive trajectories were sometimes implausible in models that did not account for PEs. The associations between grip strength and cognitive decline did not differ by the PE approach used. Constraining PEs based on estimates from a preliminary model allows for a meaningful interpretation of cognitive change.

Indexed as

Cognitive AgingCOVID-19AgingHumansLongitudinal StudiesPandemicsProspective Studiesagingcognitive functionCovid-19 pandemicperiod effectspractice effects

Identifiers

PMID37199336
PMCPMC10524983
OpenAlexW4377010818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.