Evidence map›Paper›PMID 37199278›Full record

ArticleActa ophthalmologica2024

Assessment of intraretinal hyperreflective foci using multimodal imaging in eyes with age-related macular degeneration.

Deniz Oncel, Giulia Corradetti, Ye He, Maryam Ashrafkhorasani, Muneeswar Gupta Nittala, Dwight Stambolian, Margaret A Pericak-Vance, Jonathan L Haines, Srinivas R Sadda

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Deniz OncelDoheny Eye Institute, California, Los Angeles, USA.
Giulia CorradettiDoheny Eye Institute, California, Los Angeles, USA.
Ye HeDoheny Eye Institute, California, Los Angeles, USA.
Maryam AshrafkhorasaniDoheny Eye Institute, California, Los Angeles, USA.
Muneeswar Gupta NittalaDoheny Eye Institute, California, Los Angeles, USA.ORCID https://orcid.org/0000-0002-3802-6594
Dwight StambolianOphthalmology and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Margaret A Pericak-VanceHussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Srinivas R SaddaDoheny Eye Institute, California, Los Angeles, USA.ORCID https://orcid.org/0000-0002-4939-3306
University of California, Los Angeles · USCase Western Reserve University · USUniversity of Miami · USUniversity of Pennsylvania · US

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
Epidemiology of Biomarkers of AMD ProgressionR01EY030614 · NEI · DOHENY EYE INSTITUTE · PI Jonathan L Haines, Margaret A. Pericak-Vance · 2021 to 2026
$3.0M
NEI NIH HHS R01 EY023164NEI NIH HHS R01 EY030614NEI NIH HHS R01EY030614NEI NIH HHS RO1EY023164
6 · The paper itself

Abstract

purposeThis study aimed to investigate the correspondence between intraretinal hyperreflective foci (IHRF) identified on optical coherence tomography (OCT) B-scans with hyperpigmentation on colour fundus photography (CFP) or hyperreflectivity on infrared reflectance (IR) images in eyes with age-related macular degeneration (AMD).

methodsFlash CFP, IR images and OCT B-scans obtained at the same visit were evaluated. Individual IHRF identified on OCT B-scans were assessed for the qualitative presence or absence of a hypotransmission tail into the choroid. The corresponding IR image obtained at the time of OCT acquisition was analysed for the presence or absence of hyperreflectivity in this region. The IR images were manually registered to the CFP image, and CFP images were inspected for the presence or absence of hyperpigmentation at the location of IHRF.

resultsFrom 122 eyes, a total of 494 IHRF were evaluated. For the primary analysis of qualitative presence or absence of hyperpigmentation on CFP and hyperreflectivity on IR at the locations corresponding to IHRF on OCT, 301 (61.0%) of the IHRFs demonstrated evidence of hyperpigmentation on CFP, while only 115 (23.3%) showed evidence of hyperreflectivity on IR. The qualitative determination of the presence or absence of an abnormality on CFP or IR were significantly different (p < 0.0001). 327 (66.2%) of the IHRF showed hypotransmission, and 80.4% of these IHRF showed hyperpigmentation on CFP, though only 23.9% (p < 0.0001) demonstrated hyperreflectivity on IR.

conclusionsLess than two-thirds of IHRF evident on OCT manifest as hyperpigmentation on colour photos, though IHRF with posterior shadowing are more likely to be evident as pigment. IR imaging appears to be even more poorly sensitive for visualizing IHRF.

Indexed as

HyperpigmentationMacular DegenerationFluorescein AngiographyFundus OculiHumansMultimodal ImagingRetrospective StudiesTomography, Optical Coherenceage-related macular degenerationAMDCFPcolour fundus photographyIntraretinal hyperreflective fociOCT

Identifiers

PMID37199278
PMCPMC10656356
OpenAlexW4377011449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.