Evidence map›Paper›PMID 37199227›Full record

ArticleEssays in biochemistry2023

Immunologically relevant effects of radiation therapy on the tumor microenvironment.

Claudia Galassi, Vanessa Klapp, Silvia C Formenti, Sandra Demaria, Lorenzo Galluzzi

Abstract read
In one paragraph

Article in Essays in biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudia GalassiDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, U.S.A.
Vanessa KlappTumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Silvia C FormentiDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, U.S.A.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, U.S.A.ORCID 0000-0003-4426-0499
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, U.S.A.

Funding

Radiation Effect on Immune Cells and the MicrobiomeU54CA274291 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI John Ng · 2022 to 2026
$9.1M
Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated RadiationR01CA201246 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEMARIA, SANDRA · 2016 to 2025
$3.9M
NCI NIH HHS R01 CA201246NCI NIH HHS U54 CA274291
6 · The paper itself

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Indexed as

Antineoplastic AgentsNeoplasmsHumansTumor MicroenvironmentAntineoplastic AgentsCGASICDmtDNATGFβTREG cellstype I IFN

Identifiers

PMID37199227
PMCPMC10543618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.