ArticleArteriosclerosis, thrombosis, and vascular biology2023
Life's Essential 8, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- A systematic review and meta-analysis of the association between cardiovascular health determined by life's essential 8 and risk of mortality and major non-communicable diseases.Frontiers in cardiovascular medicine · 2025Pooled it
- Polygenic Risk Scores disclosure for cardiovascular prevention: Protocol of the Personalized HeartCare (PHC) trial.PloS one · 2026Trial
- Intrinsic Capacity, Genetic Susceptibility and Incident Cardiovascular Disease Among Individuals With Diabetes: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China.Cancer science · 2026Article
- Metabolic vulnerability index and Life's Essential 8 with risk of major adverse cardiovascular events.NPJ cardiovascular health · 2026Article
- Behavioral Components of Life's Essential 8 Are More Strongly Associated with Cognitive Function than Clinical Factors in Chinese Older Adults.International journal of behavioral medicine · 2026Article
- Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke.Journal of the American Heart Association · 2026Article
- Proteomic signatures of life's essential 8 and incident atrial fibrillation among individuals with chronic kidney disease.Nutrition & metabolism · 2026Article
- Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank.BMJ open gastroenterology · 2026Article
- Lifestyle factors and cardiometabolic risk.Chinese medical journal · 2026Review
- Multiomics: the intersection of personalized nutrition in cardiometabolic diseases.Journal of translational medicine · 2026Review
- Life's essential 8 scores and acute myocardial infarction: Associations with risk, onset delay, and scenario-based preventable fraction estimates.American journal of preventive cardiology · 2026Article
- Mediation of Systemic Inflammation and Oxidative Stress Markers in the Association of Life's Crucial 9 with Periodontitis: Evidence from NHANES 2009-2014.Oral health & preventive dentistry · 2026Article
- Comparing the predictive accuracy of life's essential 8 and life's crucial 9 scores for all-cause mortality in COPD patients among US adults: a prospective cohort study.BMC public health · 2026Article
- Association of life's essential 8 with chronic respiratory disease mortality and lung health: a national cohort study.BMJ open respiratory research · 2026Article
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Neuroretinal and Photoreceptor Layer Thickness Reduction Associates With Impaired Cardiovascular Health: The UK Biobank Study.Investigative ophthalmology & visual science · 2026Article
- Life's Essential 8 and the Risk of Overall and Specific-Site Cancer Types: A Large-Scale Prospective Cohort Study.Cancer medicine · 2026Article
- The association between time-weighted cumulative life's essential 8 and aortic valve calcification.Frontiers in cardiovascular medicine · 2026Article
- Prevalence of cardiovascular-kidney-metabolic syndrome in areas of Southern China where ethnic minority populations reside: a cross-sectional study.Frontiers in endocrinology · 2026Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe American Heart Association recently released a new cardiovascular health (CVH) metric, Life's Essential 8 (LE8), for health promotion. However, the association between levels of LE8 and the risk of cardiovascular disease (CVD) outcomes is not known from a large prospective cohort. We aim to analyze the relationship between CVH, indicated by LE8, and risks of coronary heart disease (CHD), stroke, and CVD. Moreover, we sought to test whether the genetic susceptibility to CHD or stroke could be modified by LE8.
methodsA total of 137 794 participants free of CVD from the UK Biobank were included. CVH was scored using LE8 and categorized as low, moderate, and high.
resultsDuring a median of 10 years, 8595 CVD cases (6968 CHDs and 1948 strokes) were documented. A higher LE8 score was associated with remarkably lower risks of CHD, stroke, and CVD (
conclusionsHigh level of CVH, defined by LE8, was associated with significantly lower risks of CHD, stroke, and CVD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.