Evidence map›Paper›PMID 37199156›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice.

Dongyang Jiang, Hao Liu, Guofu Zhu, Xiankai Li, Linlin Fan, Faxue Zhao, Chong Xu, Shumin Wang, Yara Rose, Jordan Rhen and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Endothelial BMP6 Drives Hemodynamic-Dependent VSMCs Calcification in Carotid Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. PHACTR1 and Atherosclerosis: It's Complicated.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Dongyang Jiang *Department of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).ORCID 0000-0001-6610-4249
Hao Liu *Department of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).ORCID 0000-0003-2542-9797
Guofu Zhu *Department of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Xiankai LiDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Linlin FanDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Faxue ZhaoDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Chong XuDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Shumin WangAab Cardiovascular Research Institute, Department of Medicine and Dentistry, University of Rochester, NY (S.W., Y.R., J.R., X.X., J.P.).ORCID 0000-0003-0217-6600
Yara RoseAab Cardiovascular Research Institute, Department of Medicine and Dentistry, University of Rochester, NY (S.W., Y.R., J.R., X.X., J.P.).
Jordan RhenAab Cardiovascular Research Institute, Department of Medicine and Dentistry, University of Rochester, NY (S.W., Y.R., J.R., X.X., J.P.).ORCID 0000-0002-5110-4438
Ze YuDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Yiheng YinDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).
Yuling GuShanghai Naturethink Life Science and Technology Co, Ltd, China (Y.G.).
Xiangbin XuAab Cardiovascular Research Institute, Department of Medicine and Dentistry, University of Rochester, NY (S.W., Y.R., J.R., X.X., J.P.).
Edward A FisherDivision of Cardiology, Department of Medicine, New York University School of Medicine (E.A.F.).ORCID 0000-0001-9802-143X
Junbo GeDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).ORCID 0000-0002-9360-7332
Yawei XuDepartment of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (D.J., H.L., G.Z., X.L., L.F., F.Z., C.X., Z.Y., Y.Y., J.G., Y.X.).ORCID 0000-0002-2175-6988
Jinjiang PangAab Cardiovascular Research Institute, Department of Medicine and Dentistry, University of Rochester, NY (S.W., Y.R., J.R., X.X., J.P.).ORCID 0000-0001-6946-3941
Shanghai Tenth People's Hospital · CNUniversity of Rochester · USWorld Wide Web Consortium · USCenter for High Pressure Science & Technology Advanced Research · CNNew York University · USX-Fab (Germany) · DEYanbian University Hospital · CN

Funding

Molecular Regulation of Atherosclerosis Regression - RenewalR01HL084312 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A · 2006 to 2024
$11.4M
NHLBI NIH HHS R01 HL084312
6 · The paper itself

Abstract

backgroundNumerous genome-wide association studies revealed that SNPs (single nucleotide polymorphisms) at the

methodsWe generated global (

resultsGlobal or EC-specific

conclusionsOur results identified endothelial PHACTR1 as a novel PPARγ corepressor to promote atherosclerosis in disturbed flow regions. Endothelial PHACTR1 is a potential therapeutic target for atherosclerosis treatment.

Indexed as

AtherosclerosisPPAR gammaAnimalsCholesterolGenome-Wide Association StudyHumansMiceMice, KnockoutMicrofilament ProteinsCholesterolMicrofilament ProteinsPhactr1 protein, mousePPAR gammaPparg protein, mouseatherosclerosisblood flowendothelial cellsinflammationPPAR gamma

Identifiers

PMID37199156
PMCPMC10524336
OpenAlexW4377012014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.