ArticleNature2023
Uridine-derived ribose fuels glucose-restricted pancreatic cancer.
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In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
42.2field-weighted citation impact, top 1% of its field
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Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Metabolic phenotyping combined with transcriptomics metadata fortifies the diagnosis of early-stage Hepatocellular carcinoma.Journal of advanced research · 2025Pooled it
- Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.Food chemistry. Molecular sciences · 2026Article
- Macrophage- or neutrophil-expressed UPP1 drives tumor growth and immune suppression in the tumor microenvironment.Science advances · 2026Article
- Review
- ASS1-derived argininosuccinate promotes purine nucleoside synthesis in B cell acute lymphoblastic leukaemia.Nature metabolism · 2026Article
- Stable Isotope-Resolved Metabolomics in Elucidating Mitochondrial Metabolic Reprogramming and Therapeutic Targets.Biomedical chromatography : BMC · 2026Review
- Single-Cell Transcriptomics of Pyrimidine Salvage in HBV-Related HCC Reveals Prognostic and Immune Infiltration Features.Biomolecules & therapeutics · 2026Article
- Metabolomic Profiles and Changes During the 20 Years Preceding Heart Failure.Circulation research · 2026Article
- UPP1 in Cancer: Context-Dependent Roles in Metabolic Adaptation and Treatment Response.Current issues in molecular biology · 2026Review
- Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer.Cancer immunology research · 2026Article
- CEBPG-Mediated Palmitic Acid Adaptation of Cancer-Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic control of nucleotide metabolism in physiology and disease.Nature cell biology · 2026Review
- Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis.Cell death discovery · 2026Article
- MO-IPS suppresses acute myeloid leukemia through metabolic reprogramming and synergizes with anti-PD-1 immunotherapy.Functional & integrative genomics · 2026Article
- Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis.Journal for immunotherapy of cancer · 2026Article
- Targeted metabolomic profiling of gastric cancer biopsies.The Indian journal of medical research · 2026Article
- Pancreatic cancer.Nature reviews. Disease primers · 2026Review
- Decoding cancer across scales with metabolomics.Nature reviews. Cancer · 2026Review
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- Uridine metabolism promotes lung adenocarcinoma progression by activating FBL transcription via YBX1.Journal of translational medicine · 2026Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 4 institutions in 2 countries.
Zeribe C Nwosu *Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1641-2045
Matthew H Ward *Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Peter Sajjakulnukit *Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8556-7481
Pawan Poudel *Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
Chanthirika RagulanDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Steven KasperekDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1895-2056
Megan RadykDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Damien SuttonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Rosa E MenjivarCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Anthony AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Juan J Apiz-SaabBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Zachary TolstykaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Kristee BrownDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Ho-Joon LeeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3616-5387
Lindsey N DzierozynskiBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Xi HeDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-5802-2507
Hari PsDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Julia UgrasDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0009-0003-8389-5478
Gift NyamundandaDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Christopher J HalbrookDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3376-3114
Eileen S CarpenterDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Jiaqi ShiDepartment of Pathology and Clinical Labs, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Leah P ShriverDepartment of Chemistry, Washington University in St Louis, St Louis, MO, USA.
Gary J PattiDepartment of Chemistry, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-3748-6193
Alexander MuirBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Marina Pasca di MaglianoDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Anguraj SadanandamDivision of Molecular Pathology, The Institute of Cancer Research, London, UK. anguraj.sadanandam@icr.ac.uk.ORCID 0000-0001-8485-5150
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.ORCID 0000-0001-9309-6141
University of Michigan · USInstitute of Cancer Research · GBUniversity of Chicago · USWashington University in St. Louis · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2MVIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MMulti-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MTRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9MTraining Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MProteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9MMechanisms of Pancreatic Inflammation, Tissue Repair and CarcinogenesisR01CA151588 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2010 to 2020
$3.3MIntratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6MDefining epigenetic signaling to reshape pancreatic tumor microenvironmentR37CA262209 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiaqi Shi · 2022 to 2026
$2.3MThe 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigatorsR25GM143298 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA, RE, DIANE BERENGERE · 2021 to 2025
$2.3MBLRD VA IK2 BX005875NCI NIH HHS K08 CA234222NCI NIH HHS K99 CA267176NCI NIH HHS P30 CA014599NCI NIH HHS P30 CA046592NCI NIH HHS R00 CA241357NCI NIH HHS R01 CA151588NCI NIH HHS R01 CA198074NCI NIH HHS R01 CA244931NCI NIH HHS R01 CA248160NCI NIH HHS R37 CA237421NCI NIH HHS R37 CA262209NCI NIH HHS T32 CA009594NCI NIH HHS T32 CA140044NICHD NIH HHS T32 HD007505NIDDK NIH HHS P30 DK056341NIGMS NIH HHS R25 GM086262NIGMS NIH HHS R25 GM143298NIGMS NIH HHS T32 GM139774
Abstract
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy
Indexed as
GlucosePancreatic NeoplasmsRiboseTumor MicroenvironmentUridineAnimalsCarcinoma, Pancreatic DuctalCell DivisionCell Line, TumorHumansMAP Kinase Signaling SystemMiceProto-Oncogene Proteins p21(ras)Uridine PhosphorylaseGlucoseKRAS protein, humanProto-Oncogene Proteins p21(ras)RiboseUPP1 protein, humanUridineUridine Phosphorylase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.