Evidence map›Paper›PMID 37198487›Full record

ArticleNature2023

RNA conformational propensities determine cellular activity.

Megan L Ken, Rohit Roy, Ainan Geng, Laura R Ganser, Akanksha Manghrani, Bryan R Cullen, Ursula Schulze-Gahmen, Daniel Herschlag, Hashim M Al-Hashimi

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Key Points to Consider When Studying RNA Remodeling by Proteins.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Article
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  6. Article
  7. Review
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  12. Generative AI for computational chemistry: A roadmap to predicting emergent phenomena.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Structural basis and affinity improvement for an ATP-binding DNA aptamer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. gRNAde: Geometric Deep Learning for 3D RNA inverse design.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Megan L KenDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8336-9935
Rohit RoyCenter for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC, USA.
Ainan GengDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Laura R GanserDepartment of Biophysics, Johns Hopkins University, Baltimore, MD, USA.
Akanksha ManghraniDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Bryan R CullenDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8638-6850
Ursula Schulze-GahmenGladstone Institute of Virology, San Francisco, CA, USA. ursula.schulzegahmen@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0003-3919-4474
Daniel HerschlagDepartment of Biochemistry, Stanford University, Stanford, CA, USA. herschla@stanford.edu.ORCID http://orcid.org/0000-0002-4685-1973
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. ha2639@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-0681-1747

Funding

HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Center for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
The Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TOLBERT, BLANTON SMITH · 2019 to 2021
$15.1M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Fundamental Studies of RNA Conformational ThermodynamicsR01GM132899 · NIGMS · STANFORD UNIVERSITY · PI AL-HASHIMI, HASHIM M, HERSCHLAG, DANIEL · 2019 to 2022
$2.7M
Targeting Tat/TAR interactions with the superelongation complex to develop novel treatments for HIV/AIDSR21AI156915 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI SCHULZE-GAHMEN, URSULA · 2021 to 2022
$520k
Deciphering the principles of selective recognition of complex RNAs by small moleculesF30AI143282 · NIAID · DUKE UNIVERSITY · PI KEN, MEGAN L · 2019 to 2021
$126k
NIAID NIH HHS F30 AI143282NIAID NIH HHS R21 AI156915NIAID NIH HHS U54 AI150470NIAID NIH HHS U54 AI170660NIAID NIH HHS UM1 AI164559NIGMS NIH HHS R01 GM132899NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes

Indexed as

HIV-1HIV Long Terminal RepeatNucleic Acid ConformationRNA, Viraltat Gene Products, Human Immunodeficiency VirusTranscriptional ActivationRNA, Viraltat Gene Products, Human Immunodeficiency Virus

Identifiers

PMID37198487
PMCPMC10429349

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.