ArticleNature2023
Lysine catabolism reprograms tumour immunity through histone crotonylation.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 2 pooled it
28.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
173 citing papers in PubMed, 2 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Metabolic modulation of glioblastoma by dietary intervention: a systematic review.Journal of neuro-oncology · 2026Pooled it
- Current hotspots and trends in cancer metabolic reprogramming: a scientometric analysis.Frontiers in immunology · 2024Pooled it
- Post-translational modification-regulating biomaterials for regeneration.Bioactive materials · 2026Review
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma.Molecular cell · 2026Article
- Fine-tuning the lysine-arginine duet: a dietary approach to suppress tumor growth.Molecular biomedicine · 2026Article
- Aspirin-Derived Salicyl-CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth.Cell · 2026Article
- Epigenetic Alterations in Meningiomas-A Review.Biomedicines · 2026Review
- MOF promotes venous thromboembolism in lung cancer by activating the YBX1-MALT1-NF-κB-PAI-1 axis, possibly through histone crotonylation.The Journal of biological chemistry · 2026Article
- Histone modifications: mechanisms, metabolic regulation, and therapeutic targeting in cancer.Precision clinical medicine · 2026Review
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- PGK1-driven histone lactylation fuels MDSC-driven immune evasion and tumor progression in triple-negative breast cancer.Acta pharmacologica Sinica · 2026Article
- Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.Signal transduction and targeted therapy · 2026Article
- Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Natural Plant Bioactives as Regulators of Histone Modifications: Bridging Epigenetics and Anticancer Therapy.Phytotherapy research : PTR · 2026Review
- Review
- DHRS9 generates crotonyl-CoA from butyryl-CoA to epigenetically regulate STING transcription and potentiate immune activation.Cell death and differentiation · 2026Article
- The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.Nature communications · 2026Article
- SUMOylation activates ECHS1 for adaptive catabolism in lung cancer.Cell death & disease · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Huairui YuanHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Xujia WuHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6904-0778
Qiulian WuHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Adam ChatoffDepartment of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Emily MegillDepartment of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Jinjun GaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Tengfei HuangHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Tingting DuanHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4482-5587
Kailin YangDepartment of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Chunyu JinDepartment and School of Medicine, University of California, San Diego, CA, USA.
Fanen YuanHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Shuai WangHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Linjie ZhaoHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Pascal O ZinnHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kalil G AbdullahHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yingming ZhaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Nathaniel W SnyderDepartment of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5643-8747
Jeremy N RichHillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.ORCID http://orcid.org/0000-0001-7845-5302
UPMC Hillman Cancer Center · USTemple University · USUniversity of Chicago · USCleveland Clinic · USUniversity of California San Diego · US
Funding
Dynamic Complexity of Brain Tumor Stem Cells (R35CA197718)R35CA197718 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2015 to 2021
$6.4MHistone lactylation pathway in hair cycle: deacylases and their protein targetsR01AR078555 · NIAMS · UNIVERSITY OF CHICAGO · PI LIN, HENING, ZHAO, YINGMING · 2021 to 2025
$3.3MLactate production by tumor associated macrophages promotes tumorigenesisR01CA251677 · NCI · UNIVERSITY OF CHICAGO · PI BECKER, LEV, ZHAO, YINGMING · 2021 to 2025
$2.8MTargeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)R01CA238662 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAY, STEVE A, RICH, JEREMY N · 2020 to 2024
$2.8MSystematic screening for new histone marks and studying their epigenetic functionR01GM135504 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, YINGMING · 2020 to 2023
$2.1MQuantification of compartmentalized metabolism in eukaryotic systemsR01GM132261 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SNYDER, NATHANIEL W. · 2019 to 2023
$1.8MDual Targeting of Brain Tumor Initiating Cells through Inhibition of BMI1 and EZH2 (R01NS103434)R01NS103434 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2017 to 2021
$1.7MNCI NIH HHS R01 CA238662NCI NIH HHS R01 CA251677NCI NIH HHS R35 CA197718NIAMS NIH HHS R01 AR078555NIGMS NIH HHS R01 GM132261NIGMS NIH HHS R01 GM135504NINDS NIH HHS R01 NS103434
Abstract
Cancer cells rewire metabolism to favour the generation of specialized metabolites that support tumour growth and reshape the tumour microenvironment
Indexed as
HistonesLysineNeoplasmsProtein Processing, Post-TranslationalAcyl Coenzyme AAmino Acid Transport Systems, BasicAnimalsChromatinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseEnoyl-CoA HydrataseGlutaryl-CoA DehydrogenaseHumansInterferon-Induced Helicase, IFIH1Interferon Type IMicePeptide FragmentsAcyl Coenzyme AAmino Acid Transport Systems, Basicbone sialoprotein (35-62), humancGAS protein, humanChromatincrotonyl-coenzyme ACyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseECHS1 protein, humanEnoyl-CoA HydrataseGlutaryl-CoA DehydrogenaseHistonesIFIH1 protein, humanInterferon-Induced Helicase, IFIH1Interferon Type ILysineMYC protein, humanPDCD1 protein, humanPeptide FragmentsProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-mycRNA, Double-StrandedSialoglycoproteinsSLC7A2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.