ArticleNature2023
ERα-associated translocations underlie oncogene amplifications in breast cancer.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
40.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 115 citations in OpenAlex.
- Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Trial
- Unraveling the lexicon of complex mutational phenomena in human cancers.Nature cancer · 2026Review
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Detecting and reconstructing breakage-fusion-bridge cycles from long-read sequencing using BFBArchitect.Bioinformatics (Oxford, England) · 2026Article
- Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humans.bioRxiv : the preprint server for biology · 2026Article
- Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.Nature communications · 2026Article
- NOTCH2NLA gene amplification is associated with poor prognosis in breast cancer.Discover oncology · 2026Article
- ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8Nature communications · 2026Article
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS letters · 2026Review
- Evolution of oncogene amplification across 86,000 cancer cell genomes.bioRxiv : the preprint server for biology · 2026Article
- Topographical archetypes of somatic mutagenesis in cancer.bioRxiv : the preprint server for biology · 2026Article
- Tailoring targeted therapies for younger women with ER-positive early-stage breast cancer.Nature reviews. Clinical oncology · 2026Review
- Somatic structural variants drive upper tract urothelial carcinoma muscle invasiveness via activation of TPX2 transcription.EBioMedicine · 2026Article
- ESR1 fusions in breast cancer: functions, mechanisms and therapeutic opportunities.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026Review
- Emerin acts as a mechanosensor linking force transmission and disease.Frontiers in oncology · 2026Review
- Clinicopathological and genomic features of extrachromosomal DNA in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- ANKLE1 processes chromatin bridges by cleaving mechanically stressed DNA.Nature communications · 2025Article
- Hormonal Contraceptive Formulations and Breast Cancer Risk in Adolescents and Premenopausal Women.JAMA oncology · 2025Article
- Adherence and Compliance with Endocrine Treatment After Primary Breast Cancer Treatment: A Cross-Sectional Qualitative Study.Medicina (Kaunas, Lithuania) · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Jake June-Koo LeeDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. leej39@mskcc.org.ORCID 0000-0003-1348-4094
Youngsook Lucy Jung *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Taek-Chin Cheong *Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0939-9412
Jose Espejo Valle-InclanEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.ORCID 0000-0002-4857-5984
Chong ChuDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0796-2339
Doga C GulhanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Viktor LjungströmDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Hu JinDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Vinayak V ViswanadhamDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0236-6490
Emma V WatsonDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Isidro Cortés-CirianoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.ORCID 0000-0002-2036-494X
Stephen J ElledgeLudwig Center at Harvard, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7923-6283
Roberto ChiarleDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1564-8531
David PellmanLudwig Center at Harvard, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5306-8031
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. peter_park@hms.harvard.edu.ORCID 0000-0001-9378-960X
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USEuropean Bioinformatics Institute · GBHoward Hughes Medical Institute · USMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MRESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MPolyploidy, Aneuploidy and Genome StabilityR01CA213404 · NCI · DANA-FARBER CANCER INST · PI PELLMAN, DAVID S · 2017 to 2024
$3.5MAPOBEC proteins as drivers of chromosomal translocations in solid cancersR01CA222598 · NCI · BOSTON CHILDREN'S HOSPITAL · PI CHIARLE, ROBERTO · 2018 to 2022
$2.0MCharacterizing mechanisms and consequences of intergenic transcription in human cancersF31CA264958 · NCI · HARVARD MEDICAL SCHOOL · PI VISWANADHAM, VINAYAK VENKATASESHA · 2021 to 2022
$60kNCI NIH HHS F31 CA264958NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA213404NCI NIH HHS R01 CA222598NHGRI NIH HHS T32 HG002295NLM NIH HHS T15 LM007092
Abstract
Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure
Indexed as
Breast NeoplasmsEstrogen Receptor alphaGene AmplificationOncogenesTranslocation, GeneticCyclin D1DNA Breaks, Double-StrandedErb-b2 Receptor Tyrosine KinasesEstrogensFemaleGenome, HumanHumansOrgan SpecificityCCND1 protein, humanCyclin D1ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesESR1 protein, humanEstrogen Receptor alphaEstrogens
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.