SynthesisNature2023
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 142 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oxidative Stress-Related Genome-Wide Mendelian Randomization Identifies Causal Genes for Coronary Artery Disease.Cardiovascular therapeutics · 2026Pooled it
- PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects.BMC bioinformatics · 2024Pooled it
- Telmisartan reduces systemic inflammation and alters the renin-angiotensin system in mild COVID-19.Scientific reports · 2025Trial
- Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis.Renal failure · 2026Article
- Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study.Renal failure · 2026Article
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- Article
- Surfactant-Associated Protein D Polymorphism and Protection Against COVID-19 in the Czech Population.Immunity, inflammation and disease · 2026Article
- Genetically informed prioritization of immune checkpoint-associated genes in head and neck cancer highlights HGF and AKT1.Functional & integrative genomics · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.Science advances · 2026Article
- Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups.Genetics · 2026Article
- Metabolically and epigenetically reprogrammed splenic TRNP1Nature genetics · 2026Article
- A cross-ancestry genetic atlas of shared susceptibility between infectious diseases and cancer.Functional & integrative genomics · 2026Article
- Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells.PLoS genetics · 2026Article
- Disease-associated genetic variants can cause missense effects in tissue-specific protein isoforms.Nature communications · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.bioRxiv : the preprint server for biology · 2026Article
- Identification of macrophage polarization-related genes for esophageal cancer risk: a multi-omics Mendelian randomization analysis.Clinical epigenetics · 2026Article
- SMAD7 Downregulation Promotes Ferroptosis in Pulmonary Arterial Hypertension Via the TGF-β1-SMAD2/3 Pathway.Shock (Augusta, Ga.) · 2026Article
- Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity.Molecular medicine (Cambridge, Mass.) · 2026Article
- BiGER: Bayesian rank aggregation in genomics with extended ranking schemes.Nature communications · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
59 authors.
Erola Pairo-Castineira *Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2423-3090
Konrad Rawlik *Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0010-370X
Andrew D BretherickBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9258-3140
Ting QiSchool of Life Sciences, Westlake University, Hangzhou, China.
Yang WuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0128-7280
Isar NassiriWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Glenn A McConkeyFaculty of Biological Sciences, University of Leeds, Leeds, UK.
Marie ZechnerBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Lucija KlaricMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3105-8929
Fiona GriffithsBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Wilna OosthuyzenBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Athanasios KousathanasGenomics England, London, UK.
Anne RichmondMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Jonathan MillarBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Clark D RussellBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Tomas MalinauskasWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4847-5529
Ryan ThwaitesNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3052-2793
Kirstie MorriceEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Sean KeatingIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8552-5604
David MasloveDepartment of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada.
Alistair NicholClinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4689-1238
Malcolm G SempleNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9700-0418
Julian KnightWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Manu Shankar-HariIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5338-2538
Charlotte SummersDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7269-2873
Charles HindsWilliam Harvey Research Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-5094-8324
Peter HorbyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lowell LingDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Danny McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-3283-1947
Hugh MontgomeryUCL Centre for Human Health and Performance, London, UK.ORCID http://orcid.org/0000-0001-8797-5019
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7220-2555
Colin BeggRoyal Hospital for Children, Glasgow, UK.
Timothy WalshIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Albert TenesaMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4884-4475
Carlos FloresGenomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.
José A RianchoIDIVAL, Santander, Spain.
Augusto Rojas-MartinezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud and Hospital San Jose TecSalud, Monterrey, Mexico.
Pablo LapunzinaCentre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
GenOMICC Investigators
SCOURGE Consortium
ISARICC Investigators
23andMe COVID-19 Team
Jian YangSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0003-2001-2474
Chris P PontingMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0202-7816
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4991-3797
Malak AbedalthagafiGenomic Research Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Andre D LuchessiDepartment of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, Brazil.
Esteban J ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.
Raquel CruzCentre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Angel CarracedoCentre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Angie FawkesEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Lee MurphyEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6467-7449
Kathy RowanIntensive Care National Audit & Research Centre, London, UK.ORCID http://orcid.org/0000-0001-8217-5602
Alexandre C PereiraHeart Institute, University of Sao Paulo, Butanta, Brazil.
Andy LawRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1868-2364
Benjamin FairfaxWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7413-5002
Sara Clohisey HendryBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7489-9846
J Kenneth BaillieBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.ORCID http://orcid.org/0000-0001-5258-793X
Funding
Medical Research Council MC_PC_19025Medical Research Council MC_PC_20004Medical Research Council MC_PC_20029Medical Research Council MC_PC_20058Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00007/15Medical Research Council MR/R026408/1Medical Research Council MR/S032304/1Medical Research Council MR/V001329/1
Abstract
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown
Indexed as
COVID-19Critical IllnessGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyAdenylate KinaseCyclic Nucleotide Phosphodiesterases, Type 4GenotypeGenotyping TechniquesGlucose Transporter Type 5HumansJanus Kinase 1MonocytesPhenotyperab2 GTP-Binding Proteinrab GTP-Binding ProteinsAdenylate Kinaseadenylate kinase 5Cyclic Nucleotide Phosphodiesterases, Type 4Glucose Transporter Type 5JAK1 protein, humanJanus Kinase 1PDE4A protein, humanRAB2A protein, humanrab2 GTP-Binding Proteinrab GTP-Binding ProteinsSerine EndopeptidasesSLC2A5 protein, humanTMPRSS2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.