Evidence map›Paper›PMID 37198403›Full record

Observational studyPediatric research2023

Early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol: a retrospective cohort study.

Bella Zhong, Kenneth Tan, Abdul Razak, Vathana Sackett, Catherine Machipisa, Lindsay Zhou, Samira Samiee-Zafarghandy, Arvind Sehgal, Rod W Hunt, Pramod Pharande and 1 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Bella ZhongDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Kenneth TanDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Abdul RazakDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Vathana SackettAllied Health Department, Monash Children's Hospital, Melbourne, VIC, Australia.
Catherine MachipisaAllied Health Department, Monash Children's Hospital, Melbourne, VIC, Australia.
Lindsay ZhouDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Samira Samiee-ZafarghandyNeonatal Division, McMaster University, Hamilton, ON, Canada.
Arvind SehgalDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Rod W HuntDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Pramod Pharande *Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
Atul Malhotra *Department of Paediatrics, Monash University, Melbourne, VIC, Australia. atul.malhotra@monash.edu.ORCID http://orcid.org/0000-0001-9664-4182
Monash Children’s Hospital · AUHudson Institute of Medical Research · AUMcMaster University · CAMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParacetamol is commonly used for analgesia and patent ductus arteriosus (PDA) treatment in preterm infants. We aimed to evaluate early neurodevelopmental outcomes of extreme preterm infants exposed to paracetamol during their neonatal admission.

methodsThis retrospective cohort study included surviving infants born at <29 weeks gestation, or with a birth weight of <1000 grams. Neurodevelopmental outcomes studied were early cerebral palsy (CP) or high risk of CP diagnosis, Hammersmith Infant Neurological Examination (HINE) score and Prechtl General Movement Assessment (GMA) at 3-4 months corrected age.

resultsTwo hundred and forty-two infants were included, of which 123 were exposed to paracetamol. After adjusting for birth weight, sex and chronic lung disease, there were no significant associations between paracetamol exposure and early CP or high risk of CP diagnosis (aOR 1.46, 95% CI 0.61, 3.5), abnormal or absent GMA (aOR 0.82, 95% CI 0.37, 1.79) or HINE score (adjusted β -0.19, 95% CI -2.39, 2.01). Subgroup analysis stratifying paracetamol exposure into <180 mg/kg or ≥180 mg/kg cumulative dose found that neither had significant effects on outcomes.

conclusionsIn this cohort of extreme preterm infants, no significant association was found between exposure to paracetamol during the neonatal admission and adverse early neurodevelopment. IMPACT: Paracetamol is commonly used in the neonatal period for analgesia and patent ductus arteriosus treatment in preterm infants, although prenatal paracetamol use has been associated with adverse neurodevelopmental outcomes. Exposure to paracetamol during the neonatal admission was not associated with adverse early neurodevelopment at 3-4 months corrected age in this cohort of extreme preterm infants. The findings from this observational study is consistent with the small body of literature supporting the lack of association between neonatal paracetamol exposure and adverse neurodevelopmental outcomes in preterm infants.

Indexed as

Ductus Arteriosus, PatentPersistent Fetal Circulation SyndromeAcetaminophenBirth WeightFemaleHumansIbuprofenInfantInfant, NewbornInfant, PrematurePregnancyRetrospective StudiesAcetaminophenIbuprofen

Identifiers

PMID37198403
PMCPMC10189702
OpenAlexW4377011620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.