ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023
Exploring brain functional connectivity in patients with taste loss: a pilot study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 2 citations in OpenAlex.
- Decoding Bitter Taste Perception in Medicine-Food Homology Substances: A Multimethod Data and Sensory Assessment Approach.Foods (Basel, Switzerland) · 2026Article
- Early detection of Alzheimer's disease using the MEMORIES mnemonic.Chronic diseases and translational medicine · 2025Review
- [Development and application of gustatory evoked potentiometer].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- Advanced gustometer design for reliable recording of gustatory event-related potentials in healthy young adults.Frontiers in neuroscience · 2025Article
- Research progress and clinical application of functional magnetic resonance imaging in otolaryngology-head and neck diseases.Frontiers in neurologyReview
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4 authors at 1 institution in 1 country.
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Abstract
purposeIn a previous neuroimaging study, patients with taste loss showed stronger activations in gustatory cortices compared to people with normal taste function during taste stimulations. The aim of the current study was to examine whether there are changes in central-nervous functional connectivity in patients with taste loss.
methodsWe selected 26 pairs of brain regions related to taste processing as our regions of interests (ROIs). Functional magnetic resonance imaging (fMRI) was used to measure brain responses in seven patients with taste loss and 12 healthy controls as they received taste stimulations (taste condition) and water (water condition). The data were analysed using ROI-to-ROI functional connectivity analysis (FCA).
resultsWe observed weaker functional connectivity in the patient group between the left and right orbitofrontal cortex in the taste condition and between the left frontal pole and the left superior frontal gyrus in the water condition.
conclusionThese results suggested that patients with taste loss experience changes of functional connectivity between brain regions not only relevant to taste processing but also to cognitive functions. While further studies are needed, fMRI might be helpful in diagnosing taste loss as an additional tool in exceptional cases.
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