Evidence map›Paper›PMID 37198277›Full record

Trial reportScientific reports2023

Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation).

Ayat Abu-Elnasr Awwad, Rehab A Hasan, Mohamed Ghazy Attia Hablas, Osama Mohammad Mohammad Abdelhay, Yahia Mohmmed Ahmed Dawood, Bothina Ahmed Mohamed, Khadiga Abdallah Abd Rabou, Taghreed Mahmoud Mohamed Salem, Marwa Elhady, Gehad Nabil Abd El-Aal and 16 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Vitamin DScientific reports · 2025
    Article
  3. [Observation and analysis of Vitamin D levels in 147 children undergoing adenoidectomy and/or tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 2 countries.

Ayat Abu-Elnasr AwwadDepartment of otorhinolaryngology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Rehab A HasanDepartment of Histology and Cell Biology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Mohamed Ghazy Attia HablasDepartment of Histology and Cell Biology, Faculty of Medicine, Suez University, Suez, Egypt.
Osama Mohammad Mohammad AbdelhayDepartment of Medical Physiology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Yahia Mohmmed Ahmed DawoodDepartment of otorhinolaryngology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Bothina Ahmed MohamedDepartment of otorhinolaryngology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Khadiga Abdallah Abd RabouDepartment of otorhinolaryngology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Taghreed Mahmoud Mohamed SalemDepartment of otorhinolaryngology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Marwa ElhadyDepartment of Pediatrics, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Gehad Nabil Abd El-AalDepartment of Pediatrics, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Cairo, Egypt.
Ahmed Helal Elsayed AhmedDepartment of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed Ibrahim Mostafa HasanDepartment of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Asmaa Abd Elsalam ElmadboulyDepartment of Clinical Pathology, Faculty of Medicine for Girls (Cairo), Al-Azhar University, Cairo, Egypt.
Mohamed Basiouny YahiaDepartment of clinical pathology, Faculty of Medicine for Boys (Cairo), Al-Azhar University, Cairo, Egypt.
Walaa Mohamed Omar AshryDepartment of Medical Microbiology and Immunology, Damietta Faculty of Medicine (girls), Al-Azhar University, Damietta, Egypt.
Said S M M El SayedDepartment of Medical Physiology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Ashraf M M AlgendyDepartment of Medical Physiology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Ahmad M F AlkotDepartment of Medical Physiology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Mohamed F FaragDepartment of Physiology, Armed Forces College of Medicine, Cairo, Egypt.
Ashraf Abdel Aty El Shenawy EmaraDepartment of Medical Physiology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Fayez Mohammed Abd Elfattah ElbayoumyDepartment of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hany Fawzy AliDepartment of clinical pathology, Faculty of Medicine for Boys (Cairo), Al-Azhar University, Cairo, Egypt.
Mohamed Morshdy AldesokyDepartment of Medical Microbiology and Immunology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
Raafat Abd-Rabow Abd-EltwabDepartment of Medical Microbiology and Immunology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
Samia M ManawyDepartment of Anatomy and Embryology, Faculty of Medicine, Benha University, Benha, Egypt.
Eman Mohamed FarukDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. faruk_eman@yahoo.com.
Al-Azhar University · EGDamietta University · EGArmed Forces College of Medicine · EGBenha University · EGSuez University · EGUmm al-Qura University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory processes are increasingly attributed to macrophage polarization. Proinflammatory macrophages promote T helper (Th) 1 response, tissue repair, and Th2 responses. Detection of macrophages in tissue sections is facilitated by CD68. Our study is focused on the expression of CD68 and the estimation of proinflammatory cytokines in children's patients with chronic tonsillitis secondary to vitamin D supplementation. This hospital-based Randomized prospective case-control study was conducted on 80 children with chronic tonsillitis associated with vitamin D deficiency where (40 received vitamin D 50,000 IU weekly for 3-6 months and 40 received 5 ml distilled water as placebo). The serum 25-hydroxyvitamin D [25(OH)D] was measured using an Enzyme-linked immunosorbent assay on all included children. Different histological and immunohistochemical studies for the detection of CD68 were done. There was a significantly lower serum level of 25(OH)D in the placebo group versus the vitamin D group (P < 0.001). The levels of pro-inflammatory cytokines, TNFα, and IL-2 significantly increased in the placebo group as compared to the vitamin D group (P < 0.001). The increased level of IL-4 and IL-10 in the placebo group as compared to the vitamin D group was insignificant (P = 0.32, 0.82) respectively. Vitamin D supplementation alleviated the deleterious effect of chronic tonsillitis on the histological structure of the tonsil. Tonsillar tissues of the children in the control and vitamin D groups demonstrated a highly statistically significantly lower number of CD68 immunoexpressing cells compared with those in the placebo group (P < 0.001). Low vitamin D may play a role in chronic tonsillitis. Vitamin D supplementation could help reduce the occurrence of chronic tonsillitis in susceptible children.

Indexed as

TonsillitisVitamin D DeficiencyCase-Control StudiesCD68 MoleculeChildCholecalciferolCytokinesDietary SupplementsHumansVitamin DVitaminsCD68 antigen, humanCD68 MoleculeCholecalciferolCytokinesVitamin DVitamins

Identifiers

PMID37198277
PMCPMC10189686
OpenAlexW4377011389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.