ArticleChemistryOpen2023
Mechanochemically-Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α-Acyloxycarboxamide Derivatives.
Article in ChemistryOpen, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- Mechanochemistry to Form Substituted Imidazoles, Imidazolium Salts and NHC-Gold Complexes with Fluorine-Containing Groups.Molecules (Basel, Switzerland) · 2025Article
- Accessing Promising Passerini Adducts in Anticancer Drug Design.Molecules (Basel, Switzerland) · 2024Article
- Mechanochemically-Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α-Acyloxycarboxamide Derivatives.ChemistryOpen · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α-acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity provided by multicomponent reactions, enables the efficient synthesis of the target compounds, with great atom economy, shorter reaction times, and experimental simplicity. The method allows for the rapid production of a vast library of complex compounds from a limited number of substrates.
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