Evidence map›Paper›PMID 37198099›Full record

ArticleClinical genitourinary cancer2023

The Impact of Blue Light Cystoscopy Use Among Nonmuscle Invasive Bladder Cancer Patients in an Equal Access Setting: Implications on Recurrence and Time to Recurrence.

Sanjay Das, Lin Gu, Claire Trustram Eve, Joshua Parrish, Amanda M De Hoedt, Chad McKee, William Aronson, Stephen J Freedland, Stephen B Williams

Abstract read
In one paragraph

Article in Clinical genitourinary cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanjay DasDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC; Division of Urology, Cedars-Sinai Medical Center, Los Angeles; Department of Urology, University of California - Los Angeles, Los Angeles, CA.
Lin GuDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC; Department of Surgery, Duke Cancer Institute Biostatistics Shared Resource, Durham, NC.
Claire Trustram EveDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC.
Joshua ParrishDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC.
Amanda M De HoedtDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC.
Chad McKeeMedical Affairs, Photocure Inc., Princeton, NJ.
William AronsonDepartment of Urology, University of California - Los Angeles, Los Angeles, CA; Deaprtment of Surgery, Urology Section, Greater Los Angeles Veterans Affairs, Los Angeles, CA.
Stephen J FreedlandDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC; Division of Urology, Cedars-Sinai Medical Center, Los Angeles; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Stephen B WilliamsDepartment of Surgery, Durham Veterans Affairs Health Care System, Durham, NC; Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX. Electronic address: stbwilli@utmb.edu.

Funding

Patient-Centered Outcomes Research Training in Urologic and Gynecologic Cancers (PCORT UroGynCan)T32CA251072 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Beth Y. Karlan, MARK S. LITWIN · 2020 to 2026
$2.1M
NCI NIH HHS T32 CA251072
6 · The paper itself

Abstract

introductionPrior studies suggest that white light cystoscopy (WLC) alone can fail to detect cases of non-muscle invasive bladder cancer (NMIBC) vs. blue light cystoscopy (BLC). We describe bladder cancer outcomes and the impact of BLC among NMIBC patients in an equal access setting. MATERIALS AND

methodsWe assessed 378 NMIBC patients within the Veterans Affairs system that had a CPT code for BLC from December 1, 2014 to December 31, 2020. We determined recurrence rates and time to recurrence prior to BLC (ie, after previous WLC if available) and following BLC. We used the Kaplan-Meier method to estimate event-free survival and Cox regression to determine association between BLC and recurrence, progression, and overall survival; and further, whether these outcomes differed by race.

resultsOf 378 patients with complete data, 43 (11%) were Black and 300 (79%) White. Median follow-up was 40.7 months from bladder cancer diagnosis. Median time to first recurrence following BLC was longer vs. WLC alone (40 [33-NE] vs. 26 [17-39] months). Recurrence risk was significantly lower following BLC (Hazard Ratio [HR] 0.70; 95% Confidence Interval [CI], 0.54-0.90). There was no significant difference in recurrence (HR 0.69; 95% CI, 0.39-1.20), progression (HR 1.13; 95% CI, 0.32-3.96), and overall survival (HR 0.74; 95% CI, 0.31-1.77) following BLC by Black vs. White race.

conclusionIn this study from an equal access setting in the VA, we observed significantly decreased recurrence risk and prolonged time interval to recurrence following BLC vs. WLC alone. There was no difference in bladder cancer outcomes by race.

Indexed as

CystoscopyUrinary Bladder NeoplasmsHumansNeoplasm Recurrence, LocalProgression-Free SurvivalBladder cancerBlue lightCysviewNon-muscle invasiveOutcomesProgression

Identifiers

PMID37198099
PMCPMC10611894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.