Evidence map›Paper›PMID 37197995›Full record

ArticleNeurology2023

Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990-2030.

Jiahui Fan, Xiaoguang Li, Xueying Yu, Zhenqiu Liu, Yanfeng Jiang, Yibin Fang, Ming Zong, Chen Suo, Qiuhong Man, Lize Xiong

3 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 226 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 8 pooled it
70.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06574737 recruitingnot on this mapstarted 2024, after this paper: background citation

Use of Surface Electromyography as a Tools to Predict Upper Extremity Recovery Function After Stroke

Typeobservational_patient_registrySponsorUniversitas PadjadjaranRan2024 to 2025Enrolled30ConditionsUpper Extremity Paresis, Muscle Contracture Upper Arm, Stroke
NCT06922149 nacompletednot on this mapstarted 2025, after this paper: background citation

Effects of Functional Massage Combined With Eccentric Exercise on Muscle Tone and Motor Function of the Lower Limb in Patients With Chronic Stroke: A Pilot Randomized Clinical Trial

TypeinterventionalSponsorUniversitat Internacional de CatalunyaRan2025 to 2025Enrolled8ConditionsStrokeArmsGroup A Funtional massage therapy and eccentric exercise in lower limb, Group B. Eccentric exercises training
NCT07354321 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Thrombo-inflammation Des Maladies Neurovascualires aiguës : définition de Nouvelles Cibles thérapeutiques (TARGETS)

TypeobservationalSponsorFrançois DelvoyeRan2026 to 2032Enrolled499ConditionsDelayed Cerebral Ischemia After Subarachnoid Hemorrhage, Ischemic Stroke of Large or Medium Vessels
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 8 syntheses or guidelines pooled it, 330 citations in OpenAlex.

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  15. Back to the future: trace lead in ambient air from wood fuel combustion.Journal of exposure science & environmental epidemiology · 2026
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jiahui FanFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Xiaoguang LiFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China. lizexiong@tongji.edu.cn manqiuhong307@163.com suochen@fudan.edu.cn.
Xueying YuFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Zhenqiu LiuFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Yanfeng JiangFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Yibin FangFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Ming ZongFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China.
Chen SuoFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China. lizexiong@tongji.edu.cn manqiuhong307@163.com suochen@fudan.edu.cn.ORCID 0000-0002-5274-4584
Qiuhong ManFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China. lizexiong@tongji.edu.cn manqiuhong307@163.com suochen@fudan.edu.cn.
Lize XiongFrom the Department of Clinical Laboratory (J.F., X.Y., M.Z., Q.M.), Department of Thyroid, Breast and Vascular Surgery (X.L.), Department of Neurovascular Disease (Y.F.), and Department of Anesthesiology and Perioperative Medicine (L.X.), Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences (Z.L., Y.J.), Taizhou Institute of Health Sciences (Z.L., Y.J., C.S.), Human Phenome Institute (Z.L., Y.J.), Department of Epidemiology and Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health (C.S.), and Shanghai Institute of Infectious Disease and Biosecurity (C.S.), Fudan University; Translational Research Institute of Brain and Brain-Like Intelligence (L.X.); and Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation (L.X.), China. lizexiong@tongji.edu.cn manqiuhong307@163.com suochen@fudan.edu.cn.
Institute of Molecular Genetics · RUFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIschemic stroke (IS), 1 of the 2 main subtypes of stroke, occurs because of brain ischemia caused by thrombosis of a cerebral blood vessel. IS is one of the most important neurovascular causes of death and disability. It is affected by many risk factors, such as smoking and a high body mass index (BMI), which are also critical in the preventive control of other cardiovascular and cerebrovascular diseases. However, there are still few systematic analyses of the current and predicted disease burden and the attributable risk factors of IS.

methodsBased on the Global Burden of Disease 2019 database, we used age-standardized mortality rate and disability-adjusted life year to systematically present the geographical distribution and trends of IS disease burden worldwide from 1990 to 2019 by calculating the estimated annual percentage change and to analyze and predict the death number of IS accounted by 7 major risk factors for 2020-2030.

resultsBetween 1990 and 2019, the global number of IS deaths increased from 2.04 million to 3.29 million and is expected to increase further to 4.90 million by 2030. The downward trend was more pronounced in women, young people, and high sociodemographic index (SDI) regions. At the same time, a study of attributable risk factors of IS found that 2 behavioral factors, smoking and diet in high sodium, and 5 metabolic factors, including high systolic blood pressure, high low-density lipoprotein cholesterol, kidney dysfunction, high fasting plasma glucose, and a high BMI, are major contributors to the increased disease burden of IS now and in the future. DISCUSSION: Our study provides the first comprehensive summary for the past 30 years and the prediction of the global burden of IS and its attributable risk factors until 2030, providing detailed statistics for decision-making on the prevention and control of IS globally. An inadequate control of the 7 risk factors would lead to an increased disease burden of IS in young people, especially in low SDI regions. Our study identifies high-risk populations and helps public health professionals develop targeted preventive strategies to reduce the global disease burden of IS.

Indexed as

Ischemic StrokeAdolescentFemaleGlobal HealthHumansQuality-Adjusted Life YearsRisk AssessmentRisk FactorsSmoking

Identifiers

PMID37197995
PMCPMC10351546
OpenAlexW4376867934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.