Evidence map›Paper›PMID 37197993›Full record

ArticleNeurology2023

Association of Physical Activity and Parkinson Disease in Women: Long-term Follow-up of the E3N Cohort Study.

Berta Portugal, Fanny Artaud, Isabelle Degaey, Emmanuel Roze, Agnès Fournier, Gianluca Severi, Marianne Canonico, Cécile Proust-Lima, Alexis Elbaz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Revisiting the Association Between Calcium Channel Blockers and Parkinson's Disease in the E3N Cohort.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Article
  5. Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026
    Review
  6. Article
  7. An International Physical Exercise Screening Questionnaire (IPESQ).International journal of emergency medicine · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Meaning in life and Parkinson's disease in the UK Biobank.Clinical parkinsonism & related disorders · 2024
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Berta PortugalFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Fanny ArtaudFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Isabelle DegaeyFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Emmanuel RozeFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.ORCID 0000-0001-9727-3459
Agnès FournierFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Gianluca SeveriFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Marianne CanonicoFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Cécile Proust-LimaFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France.
Alexis ElbazFrom the Université Paris-Saclay (B.P., F.A., I.D., A.F., G.S., M.C., A.E.), UVSQ, Univ. Paris-Sud, Gustave Roussy, Inserm, U1018, Team "Exposome, Heredity, Cancer, and Health," CESP, Villejuif; Neurology Department (E.R.), Hôpital Pitié-Salpêtrière, AP-HP; Sorbonne Université (E.R.); INSERM U1127 (E.R.), CNRS 7225, Brain Institute, Paris, France; Department of Statistics (G.S.), Computer Science, Applications "G. Parenti" (DISIA), University of Florence, Italy; and Université Bordeaux (C.P.-L.), Inserm, Bordeaux Population Health Research Center, UMR1219, France. alexis.elbaz@inserm.fr.ORCID 0000-0001-9724-5490
Université Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPrevious cohort studies reported that a single measure of physical activity (PA) assessed at baseline was associated with lower Parkinson disease (PD) incidence, but a meta-analysis suggested that this association was restricted to men. Because of the long prodromal phase of the disease, reverse causation could not be excluded as a potential explanation. Our objective was to study the association between time-varying PA and PD in women using lagged analyses to address the potential for reverse causation and to compare PA trajectories in patients before diagnosis and matched controls.

methodsWe used data from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (1990-2018), a cohort study of women affiliated with a national health insurance plan for persons working in education. PA was self-reported in 6 questionnaires over the follow-up. As questions changed across questionnaires, we created a time-varying latent PA (LPA) variable using latent process mixed models. PD was ascertained using a multistep validation process based on medical records or a validated algorithm based on drug claims. We set up a nested case-control study to examine differences in LPA trajectories using multivariable linear mixed models with a retrospective timescale. Cox proportional hazards models with age as the timescale and adjusted for confounders were used to estimate the association between time-varying LPA and PD incidence. Our main analysis used a 10-year lag to account for reverse causation; sensitivity analyses used 5-, 15-, and 20-year lags.

resultsAnalyses of trajectories (1,196 cases and 23,879 controls) showed that LPA was significantly lower in cases than in controls throughout the follow-up, including 29 years before diagnosis; the difference between cases and controls started to increase ∼10 years before diagnosis ( DISCUSSION: Higher PA level is associated with lower PD incidence in women, not explained by reverse causation. These results are important for planning interventions for PD prevention.

Indexed as

Parkinson DiseaseCase-Control StudiesCohort StudiesExerciseFemaleFollow-Up StudiesHumansIncidenceRetrospective StudiesRisk Factors

Identifiers

PMID37197993
PMCPMC10435054
OpenAlexW4376867794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.