Evidence map›Paper›PMID 37197931›Full record

ArticleJournal of neurointerventional surgery2024

Preliminary experience with diffuse correlation spectroscopy in acute ischemic stroke neurointerventional procedures.

Maxim Mokin, Shail Thanki, Penaz Parveen Sultana Mohammad, Steve Sheehy, Kassandra M Jade, Ivo Peto, Waldo R Guerrero, Kunal Vakharia, W Scott Burgin, Ashwin B Parthasarathy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurointerventional surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maxim MokinDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA mokin@usf.edu.ORCID 0000-0003-4270-8667
Shail ThankiDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.ORCID 0000-0003-1164-8737
Penaz Parveen Sultana MohammadDepartment of Electrical Engineering, University of South Florida, Tampa, Florida, USA.
Steve SheehyDepartment of Electrical Engineering, University of South Florida, Tampa, Florida, USA.
Kassandra M JadeDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.
Ivo PetoDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.
Waldo R GuerreroDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.
Kunal VakhariaDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, USA.
W Scott BurginDepartment of Neurology, University of South Florida College of Medicine, Tampa, Florida, USA.
Ashwin B ParthasarathyDepartment of Electrical Engineering, University of South Florida, Tampa, Florida, USA.
University of South Florida · US

Funding

Noninvasive monitoring of cerebrovascular autoregulation during and after endovascular therapy for acute ischemic strokeR21NS130495 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI MOKIN, MAXIM, PARTHASARATHY, ASHWIN BHARADWAJ · 2023 to 2024
$402k
NINDS NIH HHS R21 NS130495
6 · The paper itself

Abstract

backgroundDiffuse correlation spectroscopy (DCS) is a non-invasive optical technique that enables continuous blood flow measurements in various organs, including the brain. DCS quantitatively measures blood flow from temporal fluctuations in the intensity of diffusely reflected light caused by the dynamic scattering of light from moving red blood cells within the tissue.

methodsWe performed bilateral cerebral blood flow (CBF) measurements using a custom DCS device in patients undergoing neuroendovascular interventions for acute ischemic stroke. Experimental, clinical, and imaging data were collected in a prospective manner.

resultsThe device was successfully applied in nine subjects. There were no safety concerns or interference with the standard angiography suite or intensive care unit workflow. Six cases were selected for final analysis and interpretation. DCS measurements with photon count rates greater than 30 KHz had sufficient signal-to-noise to resolve blood flow pulsatility. We found an association between angiographic changes in cerebral reperfusion (partial or complete reperfusion established in stroke thrombectomy cases; temporary flow arrest during carotid artery stenting) and those observed intraprocedurally with CBF measurements via DCS. Limitations of the current technology included sensitivity to the interrogated tissue volume under the probe and the effect of local changes in tissue optical properties on the accuracy of CBF estimates.

conclusionOur initial experience with DCS in neurointerventional procedures showed the feasibility of this non-invasive approach in providing continuous measurement of regional CBF brain tissue properties.

Indexed as

Cerebrovascular CirculationEndovascular ProceduresIschemic StrokeSpectrum AnalysisAgedAged, 80 and overBrain IschemiaFemaleHumansMaleMiddle AgedProspective StudiesThrombectomyBlood FlowLaserStroke

Identifiers

PMID37197931
PMCPMC10654255
OpenAlexW4376870810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.