Evidence map›Paper›PMID 37197826›Full record

ArticleRNA (New York, N.Y.)2023

tRNA

Gabriel Silveira d'Almeida, Ananth Casius, Jeremy C Henderson, Sebastian Knuesel, Ruslan Aphasizhev, Inna Aphasizheva, Aidan C Manning, Todd M Lowe, Juan D Alfonzo

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gabriel Silveira d'AlmeidaDepartment of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
Ananth CasiusDepartment of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.ORCID 0000-0002-7842-8926
Jeremy C HendersonDepartment of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
Sebastian KnueselDepartment of Molecular and Cell Biology, Boston University School of Dental Medicine, Boston 02118, USA.
Ruslan AphasizhevDepartment of Molecular and Cell Biology, Boston University School of Dental Medicine, Boston 02118, USA.ORCID 0000-0002-4595-6618
Inna AphasizhevaDepartment of Molecular and Cell Biology, Boston University School of Dental Medicine, Boston 02118, USA.ORCID 0000-0003-2695-2950
Aidan C ManningDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA.ORCID 0000-0001-9369-6008
Todd M LoweDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA.
Juan D AlfonzoDepartment of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA alfonzo.1@osu.edu.
The Ohio State University · USBoston University · USUniversity of California, Santa Cruz · US

Funding

A Unified Atlas of Dynamic tRNA FunctionR01HG006753 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOWE, TODD MICHAEL · 2012 to 2022
$4.6M
REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMESR01AI113157 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AFASIZHEVA, INNA · 2015 to 2024
$4.6M
tRNA editing by deamination: Balancing affinity and specifictyR01GM084065 · NIGMS · OHIO STATE UNIVERSITY · PI ALFONZO, JUAN D · 2008 to 2021
$4.0M
TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMESR01AI152408 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AFASIZHEV, RUSLAN · 2020 to 2024
$2.1M
Study of queuosine salvage and function in eukaryotes; a forgotten micronutrientR01GM132254 · NIGMS · UNIVERSITY OF FLORIDA · PI ALFONZO, JUAN D, DE CRECY-LAGARD, VALERIE A · 2019 to 2022
$1.6M
RNA Uridylation in TrypanosomesR56AI168191 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AFASIZHEV, RUSLAN · 2022 to 2022
$642k
NHGRI NIH HHS R01 HG006753NIAID NIH HHS R01 AI113157NIAID NIH HHS R01 AI152408NIAID NIH HHS R56 AI168191NIGMS NIH HHS R01 GM084065NIGMS NIH HHS R01 GM132254
6 · The paper itself

Abstract

Following transcription, tRNAs undergo a series of processing and modification events to become functional adaptors in protein synthesis. Eukaryotes have also evolved intracellular transport systems whereby nucleus-encoded tRNAs may travel out and into the nucleus. In trypanosomes, nearly all tRNAs are also imported from the cytoplasm into the mitochondrion, which lacks tRNA genes. Differential subcellular localization of the cytoplasmic splicing machinery and a nuclear enzyme responsible for queuosine modification at the anticodon "wobble" position appear to be important quality control mechanisms for tRNA

Indexed as

Trypanosoma brucei bruceiHalf-LifeRNA, TransferRNA, Transfer, AspRNA, Transfer, TyrRNA, TransferRNA, Transfer, AspRNA, Transfer, Tyractinomycinhalf-lifetRNAtrypanosoma

Identifiers

PMID37197826
PMCPMC10351884
OpenAlexW4376878434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.