Contrast- and noise-dependent spatial resolution measurement for deep convolutional neural network-based noise reduction in CT using patient data.

Deep convolutional neural network (DCNN)-based noise reduction methods have been increasingly deployed in clinical CT. Accurate assessment of their spatial resolution properties is required. Spatial resolution is typically measured on physical phantoms, which may not represent the true performance of DCNN in patients as it is typically trained and tested with patient images and the generalizability of DNN to physical phantoms is questionable. In this work, we proposed a patient-data-based framework to measure the spatial resolution of DCNN methods, which involves lesion- and noise-insertion in projection domain, lesion ensemble averaging, and modulation transfer function measurement using an oversampled edge spread function from the cylindrical lesion signal. The impact of varying lesion contrast, dose levels, and CNN denoising strengths were investigated for a ResNet-based DCNN model trained using patient images. The spatial resolution degradation of DCNN reconstructions becomes more severe as the contrast or radiation dose decreased, or DCNN denoising strength increased. The measured 50%/10% MTF spatial frequencies of DCNN with highest denoising strength were (-500 HU:0.36/0.72 mm