Evidence map›Paper›PMID 37197667›Full record

ArticleFrontiers in immunology2023

Prasanna Kumar Vaddi, Douglas Grant Osborne, Andrew Nicklawsky, Nazanin K Williams, Dinoop Ravindran Menon, Derek Smith, Jonathan Mayer, Anna Reid, Joanne Domenico, Giang Huong Nguyen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  8. Review
  9. miRNAs and T cell-mediated Immune Response in Disease.The Yale journal of biology and medicine · 2025
    Review
  10. Article
  11. CD39Frontiers in oncology · 2025
    Review
  12. Review
  13. Review
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Prasanna Kumar VaddiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Douglas Grant OsborneDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Andrew NicklawskyUniversity of Colorado Cancer Center Biostatistics Core, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Nazanin K WilliamsDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Dinoop Ravindran MenonDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Derek SmithDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Jonathan MayerDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Anna ReidDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Joanne DomenicoDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Giang Huong NguyenDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
William A RobinsonDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Melanie ZimanSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Dexiang GaoUniversity of Colorado Cancer Center Biostatistics Core, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Zili ZhaiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Mayumi FujitaDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · USThe University of Western Australia · AUUniversity of Colorado Cancer Center · USUniversity of Colorado Denver · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Transgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOGAN, CHRISTOPHER J · 2009 to 2018
$6.2M
The role of IL-37 in human regulatory T cells, SupplementR01AI156534 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2025
$3.0M
Modulation of Inflammasome-mediated cytokine activation by EGCG in human melanomaR01CA197919 · NCI · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2016 to 2020
$1.9M
Developing a protocol for profiling blood markers of melanomaR03CA125833 · NCI · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2008 to 2009
$154k
BLRD VA I01 BX001228NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA197919NCI NIH HHS R03 CA125833NIAID NIH HHS R01 AI156534NIAMS NIH HHS P30 AR057212
6 · The paper itself

Abstract

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immune checkpoint expressed in regulatory T (Treg) cells and activated T lymphocytes. Despite its potential as a treatment strategy for melanoma, CTLA-4 inhibition has limited efficacy. Using data from The Cancer Genome Atlas (TCGA) melanoma database and another dataset, we found that decreased

Indexed as

MelanomaMicroRNAsNeoplasms, Second PrimaryAustraliaCTLA-4 AntigenHumansPrognosisT-Lymphocytes, RegulatoryCTLA-4 AntigenCTLA4 protein, humanMicroRNAsMIRN155 microRNA, humanbiomarkerCTLA-4melanomamiRNA-155regulatory T cells

Identifiers

PMID37197667
PMCPMC10183574
OpenAlexW4367627565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.