Evidence map›Paper›PMID 37197322›Full record

ArticleJBMR plus2023

Fracture Risk in Men and Women With Vertebral Fractures Identified Opportunistically on Routine Computed Tomography Scans and Not Treated for Osteoporosis: An Observational Cohort Study.

Michael Kriegbaum Skjødt, Joeri Nicolaes, Christopher Dyer Smith, Kim Rose Olsen, Cyrus Cooper, Cesar Libanati, Bo Abrahamsen

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  14. Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Michael Kriegbaum SkjødtDepartment of Medicine Holbæk Hospital Holbæk Denmark.ORCID https://orcid.org/0000-0002-2109-8989
Joeri NicolaesUCB Pharma Brussels Belgium.ORCID https://orcid.org/0000-0003-2789-8781
Christopher Dyer SmithOPEN-Open Patient data Explorative Network, Department of Clinical Research University of Southern Denmark and Odense University Hospital Odense Denmark.
Kim Rose OlsenDaCHE, Institute of Public Health University of Southern Denmark Odense Denmark.
Cyrus CooperMRC Lifecourse Epidemiology Center University of Southampton, Southampton General Hospital Southampton UK.ORCID https://orcid.org/0000-0003-3510-0709
Cesar LibanatiUCB Pharma Brussels Belgium.ORCID https://orcid.org/0000-0003-1427-7839
Bo AbrahamsenDepartment of Medicine Holbæk Hospital Holbæk Denmark.ORCID https://orcid.org/0000-0002-2730-6080
University of Southern Denmark · DKUCB Pharma (Belgium) · BESouthampton General Hospital · GB

Funding

Medical Research Council G0400491Medical Research Council G0601019Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_PC_21022Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MR/J000094/1
6 · The paper itself

Abstract

Vertebral fractures (VFs) have been associated with future fractures, yet few studies have evaluated whether this pertains to VFs available for identification on routine radiological imaging. We sought to evaluate the risk of subsequent fractures in subjects with VF identified opportunistically on computed tomography (CT) scans performed as part of routine clinical practice. From the radiology database of Holbæk Hospital we identified the first CT scan including the thorax and/or abdomen of 2000 consecutive men and women aged 50 years or older, performed from January 1, 2010 onward. The scans were assessed in a blinded approach to identify chest and lumbar VF, and these data linked to national Danish registers. Subjects were excluded if treated with an osteoporosis medication (OM) in the year prior to baseline (date of CT), and the remaining subjects with VF matched on age and sex in 1:2 ratio against subjects with no VF. We found that the risk of major osteoporotic fractures (hip, non-cervical vertebral, humerus, and distal forearm fractures) was higher for subjects with VF than without VF: incidence rates (IRs) were 32.88 and 19.59 fractures per 1000 subject-years, respectively, and the adjusted hazard ratio (HR

Indexed as

FRACTURE PREVENTIONHEALTH SERVICES RESEARCHOSTEOPOROSISRADIOLOGYSCREENING

Identifiers

PMID37197322
PMCPMC10184021
OpenAlexW4321080564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.