Evidence map›Paper›PMID 37197154›Full record

ArticlePhysics and imaging in radiation oncology2023

A survey of practice patterns for adaptive particle therapy for interfractional changes.

Petra Trnkova, Ye Zhang, Toshiyuki Toshito, Ben Heijmen, Christian Richter, Marianne C Aznar, Francesca Albertini, Alessandra Bolsi, Juliane Daartz, Antje C Knopf and 1 more

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials.International journal of radiation oncology, biology, physics · 2026
    Guideline
  2. Article
  3. Article
  4. Maintaining quality of scientific peer-review and publishing inPhysics and imaging in radiation oncology · 2026
    Article
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  9. Review
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  16. Article
  17. Physics and imaging in radiation oncology · 2024
    Article
  18. The role of 4D particle therapy in daily patient care and research.Physics and imaging in radiation oncology · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Petra TrnkovaDepartment of Radiation Oncology, Medical University of Vienna, Vienna, Austria.
Ye ZhangCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Toshiyuki ToshitoNagoya Proton Therapy Center, Nagoya City University West Medical Center, Nagoya, Japan.
Ben HeijmenDepartment of Radiotherapy, Erasmus University Medical Center (Erasmus MC), Rotterdam, the Netherlands.
Christian RichterOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.
Marianne C AznarDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Francesca AlbertiniCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Alessandra BolsiCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Juliane DaartzDepartment of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, United States of America.
Antje C KnopfCenter for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Jenny BertholetDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Anatomical changes may compromise the planned target coverage and organs-at-risk dose in particle therapy. This study reports on the practice patterns for adaptive particle therapy (APT) to evaluate current clinical practice and wishes and barriers to further implementation. Materials and methods: An institutional questionnaire was distributed to PT centres worldwide (7/2020-6/2021) asking which type of APT was used, details of the workflow, and what the wishes and barriers to implementation were. Seventy centres from 17 countries participated. A three-round Delphi consensus analysis (10/2022) among the authors followed to define recommendations on required actions and future vision. Results: Out of the 68 clinically operational centres, 84% were users of APT for at least one treatment site with head and neck being most common. APT was mostly performed offline with only two online APT users (plan-library). No centre used online daily re-planning. Daily 3D imaging was used for APT by 19% of users. Sixty-eight percent of users had plans to increase their use or change their technique for APT. The main barrier was "lack of integrated and efficient workflows". Automation and speed, reliable dose deformation for dose accumulation and higher quality of in-room volumetric imaging were identified as the most urgent task for clinical implementation of online daily APT. Conclusion: Offline APT was implemented by the majority of PT centres. Joint efforts between industry research and clinics are needed to translate innovations into efficient and clinically feasible workflows for broad-scale implementation of online APT.

Indexed as

Adaptive radiotherapy (ART)Adaptive treatment planningImage guided particle therapyInterfraction anatomical variationParticle/proton therapy

Identifiers

PMID37197154
PMCPMC10183663

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.