ArticleNeuroImage2023
Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Can digital brain twins dissolve the uncertainties surrounding unresponsive wakefulness?BMC medical ethics · 2026Article
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Shifts in brain dynamics and drivers of consciousness state transitions.Frontiers in computational neuroscience · 2026Article
- Article
- A shared central thalamus mechanism underlying diverse recoveries in disorders of consciousness.Nature communications · 2025Article
- Individual trajectories for recovery of neocortical activity in disorders of consciousness.PLoS computational biology · 2025Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.Nature computational science · 2025Article
- Metastability demystified - the foundational past, the pragmatic present and the promising future.Nature reviews. Neuroscience · 2025Review
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Neural mass modeling for the masses: Democratizing access to whole-brain biophysical modeling with FastDMF.Network neuroscience (Cambridge, Mass.) · 2024Article
- Content-state dimensions characterize different types of neuronal markers of consciousness.Neuroscience of consciousness · 2024Article
- Psychedelics and disorders of consciousness: the current landscape and the path forward.Neuroscience of consciousness · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
Corrections and comments
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Authors and funding
18 authors at 15 institutions in 11 countries.
Funding
Abstract
Disorders of consciousness are complex conditions characterised by persistent loss of responsiveness due to brain injury. They present diagnostic challenges and limited options for treatment, and highlight the urgent need for a more thorough understanding of how human consciousness arises from coordinated neural activity. The increasing availability of multimodal neuroimaging data has given rise to a wide range of clinically- and scientifically-motivated modelling efforts, seeking to improve data-driven stratification of patients, to identify causal mechanisms for patient pathophysiology and loss of consciousness more broadly, and to develop simulations as a means of testing in silico potential treatment avenues to restore consciousness. As a dedicated Working Group of clinicians and neuroscientists of the international Curing Coma Campaign, here we provide our framework and vision to understand the diverse statistical and generative computational modelling approaches that are being employed in this fast-growing field. We identify the gaps that exist between the current state-of-the-art in statistical and biophysical computational modelling in human neuroscience, and the aspirational goal of a mature field of modelling disorders of consciousness; which might drive improved treatments and outcomes in the clinic. Finally, we make several recommendations for how the field as a whole can work together to address these challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.