ArticleJournal of affective disorders2023
Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database.
Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2024Trial
- Mechanisms of weight gain associated with valproic acid: a scoping review.European archives of psychiatry and clinical neuroscience · 2026Article
- Investigating the Use of Antidepressants in Treating Major Depressive Disorder:Saudi medical journal · 2026Article
- Associations of six dietary patterns with all-cause and cause-specific mortality among individuals with depression in the UK biobank: a prospective cohort study.European journal of nutrition · 2026Article
- Ceramides and neuroinflammation as immunometabolic drivers and biomarkers of major depressive disorder, treatment-resistant depression, and suicidal vulnerability.Frontiers in pharmacology · 2026Review
- Weight matters: Higher BMI is associated with changes in the brain connectome in health and depression.Neuroscience applied · 2026Article
- Body mass index mediates the relationship between depression and triglyceride levels: Evidence from a large national cohort.Journal of affective disorders · 2025Article
- Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.Journal of translational medicine · 2025Article
- Uncovering the genetic underpinnings for different psychiatric disorder combinations.Psychological medicine · 2025Article
- Association of Parental Feeding Styles with Body Composition Among Children in Two Regions in China.Nutrients · 2025Article
- Explainable Machine Learning in the Prediction of Depression.Diagnostics (Basel, Switzerland) · 2025Article
- Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions.Translational psychiatry · 2025Article
- Association among obesity, insulin resistance, and depressive symptoms: a mediation analysis.BMC psychiatry · 2025Article
- The joint and interactive effects of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and body mass index on the risk of depression, as well as the mediating role of NHHR: results from NHANES 2005-2023.Lipids in health and disease · 2025Article
- Clinical features of overweight in acute-phase hospitalised major depressive disorder with comorbid anxiety: a cross-sectional study.BMJ open · 2025Article
- Metabolomic Changes in Major Depressive Disorder Adolescent Females with or without Suicide Attempts.Current neuropharmacology · 2025Article
- Immuno-metabolic depression: from concept to implementation.The Lancet regional health. Europe · 2025Review
- Association between weight perception and perceived stress among Korean adults from the Korea National Health and Nutrition Examination Survey.Scientific reports · 2024Article
- Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 7 countries.
Funding
Abstract
backgroundIndividuals with major depressive disorder (MDD) are at higher risk for obesity. In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse, suicide risk also appears to be elevated in obese patients. This study used data from the European Group for the Study of Resistant Depression (GSRD) to investigate clinical outcomes associated with body mass index (BMI) in MDD.
methodsData were drawn from 892 participants with MDD over the age of 18 years (580 female, 50.5 ± 13.6 years). Response and resistance to antidepressant medication, depression rating scale scores, and further clinical and sociodemographic variables were compared using multiple logistic and linear regressions controlled for age, sex, and risk of weight gain due to psychopharmacotherapy.
resultsOf the 892 participants, 323 were categorized as treatment-responsive and 569 as treatment-resistant. Within this cohort, 278 (31.1 %) were overweight (BMI = 25-29.9 kg/m LIMITATIONS: Data were analyzed in a retrospective, cross-sectional design. BMI was used as an exclusive measure of overweight and obesity.
conclusionsParticipants with comorbid MDD and overweight/obesity were at risk for worse clinical outcomes, suggesting that weight gain should be closely monitored in individuals with MDD in daily clinical practice. Further studies are needed to explore the neurobiological mechanisms linking elevated BMI to impaired brain health.
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Registered trials
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