ArticleNature2023
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 101 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
24.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- The romantic history of signaling pathway discovery in cell death: an updated review.Molecular and cellular biochemistry · 2024Pooled it
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.Nature structural & molecular biology · 2026Article
- NINJ1: implications for plasma membrane rupture and disease.Biochemical Society transactions · 2026Review
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Ninjurin-1 mediates hepatic ischemia-reperfusion injury.Science advances · 2026Article
- SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy.Acta pharmacologica Sinica · 2026Article
- DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immune Targeting of Oligomeric Ninjurin 1 Protects Against Myocardial Infarction in Mice.Circulation research · 2026Article
- Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026Review
- Metastatic Cancers Exploit Vagal Sensory Neurons and Neural Repair Programs to Colonize New Tissues.Research square · 2026Article
- Ninjurins regulate hematopoietic stem cell amplification through canonical WNT signaling independent of plasma membrane rupture.Nature communications · 2026Article
- Surveying the roles of NINJ1 in plasma membrane rupture.Nature structural & molecular biology · 2026Article
- Review
- Threat assessment shapes neutrophil cell fate upon inflammasome activation.Science advances · 2026Article
- NINJ1 plays a vital role in the release of neutrophil extracellular traps during acute lung injury.Cell death & disease · 2026Article
- The signaling and regulatory functions of dying cells and cell corpses.Communications biology · 2026Review
- Research Progress on NINJ1-Mediated Plasma Membrane Rupture Regulation of Pathogen Infection Process.International journal of molecular sciences · 2026Review
- Ubc9-mediated SUMOylation of Ninj1 alleviates inflammatory responses in hepatic ischaemia/reperfusion injury.Clinical and translational medicine · 2026Article
- NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression.Cell death and differentiation · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
29 authors at 3 institutions in 3 countries.
Nobuhiko Kayagaki *Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. kayagaki@gene.com.ORCID http://orcid.org/0000-0001-8129-1740
Irma B Stowe *Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Kamela AlegreDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Ishan DeshpandeDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Shuang WuDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Zhonghua LinDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Opher S KornfeldDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Bettina L LeeDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Juan ZhangDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
John LiuDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Eric SutoDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2631-015X
Wyne P LeeDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Kellen SchneiderDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
WeiYu LinDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Dhaya SeshasayeeDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Tushar BhangaleDepartment of Human Genetics, Genentech, South San Francisco, CA, USA.
Cecile ChalouniDepartment of Pathology, Genentech, South San Francisco, CA, USA.
Matthew C JohnsonDepartment of Structural Biology, Genentech, South San Francisco, CA, USA.
Prajakta JoshiDepartment of Biomolecular Resources, Genentech, South San Francisco, CA, USA.
Jan MossemannProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Sarah ZhaoProgram in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Danish AliProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Neil M GoldenbergProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Blayne A SayedProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3224-8871
Benjamin E SteinbergProgram in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-3070-0548
Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4197-0340
Joshua D WebsterDepartment of Pathology, Genentech, South San Francisco, CA, USA.
Ryan L KellyDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5003-9104
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.ORCID http://orcid.org/0000-0001-6983-0326
Hospital for Sick Children · CAATUM (United States) · USGene Therapy Laboratory · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1
Indexed as
Antibodies, MonoclonalCell MembraneInflammationLiverNerve Growth FactorsReperfusion InjuryAlanine TransaminaseAlarminsAnimalsAspartate AminotransferasesCell Adhesion Molecules, NeuronalCell DeathConcanavalin AGalactosamineHepatocytesLactate DehydrogenasesAlanine TransaminaseAlarminsAntibodies, MonoclonalAspartate AminotransferasesCell Adhesion Molecules, NeuronalConcanavalin AGalactosamineLactate DehydrogenasesNerve Growth FactorsNinj1 protein, mouse
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.