ArticleScience advances2023
Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 83 citations in OpenAlex.
- Polylactic Acid-Based Biodegradable Room-Temperature Phosphorescent Materials: A Review.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- A Deep-Red Emissive Cage-in-Rings Complex for Lysosome Imaging.Angewandte Chemie (International ed. in English) · 2026Article
- Molecular orbital node engineering in pyrene: linking chemical reactivity with room-temperature phosphorescence.National science review · 2026Article
- Recent Advances of Organic Room Temperature Phosphorescence for Biological Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Emerging landscape of oncogenic signaling pathways in cervical cancer.Discover oncology · 2026Review
- High energy triplet-state manipulation via temperature-responsive twisted hetero-annulation systems.Nature communications · 2026Article
- Programmable macrophage-polarizing nanoparticles for MRI-guided early detection and treatment of pulmonary metastases.Journal of nanobiotechnology · 2025Article
- Coupling Organic Ultralong Lifetime Phosphorescence Materials with Paper-Based Bioanalytical Architectures for Autofluorescence-Free Sensing.ACS sensors · 2025Article
- A universal strategy for multicolor organic circularly polarized afterglow materials with high dissymmetry factors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aqueous up-conversion organic phosphorescence and tunable dual emission in a single-molecular emitter.Chemical science · 2025Article
- Activatable red/near-infrared aqueous organic phosphorescence probes for improved time-resolved bioimaging.National science review · 2025Article
- Activity-Based Dicyanoisophorone Derivatives: Fluorogenic Toolbox Enables Direct Visualization and Monitoring of Esterase Activity in Tumor Models.Analytical chemistry · 2024Article
- Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis.Asian journal of pharmaceutical sciences · 2024Article
- Accumulated in-situ spectral information analysis of room-temperature phosphorescence with time-gated bioimaging.Materials today. Bio · 2024Article
- Simultaneously enhancing organic phosphorescence quantum yields and lifetimes for triphenylphosphine salt doped polymer films.Chemical science · 2024Article
- Management of triplet excitons transition: fine regulation of Förster and dexter energy transfer simultaneously.Light, science & applications · 2024Article
- The Current Status and Future Directions on Nanoparticles for Tumor Molecular Imaging.International journal of nanomedicine · 2024Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis is the leading cause of cancer-related deaths; until now, the detection of tumor metastasis is mainly located at the period that secondary tumors have been formed, which usually results in poor prognosis. Thus, fast and precise positioning of organs, where tumor metastases are likely to occur at its earliest stages, is essential for improving patient outcomes. Here, we demonstrated a phosphorescence imaging method by organic nanoparticles to detect early tumor metastasis progress with microenvironmental changes, putting the detection period ahead to the formation of secondary tumors. In the orthotopic and simulated hematological tumor metastasis models, the microenvironmental changes could be recognized by phosphorescence imaging at day 3, after tumor implantation in liver or intravenous injection of cancer cells. It was far ahead those of other reported imaging methods with at least 7 days later, providing a sensitive and convenient method to monitor tumor metastases at the early stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.