Evidence map›Paper›PMID 37195918›Full record

ArticlePloS one2023

Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy: Qualitative insights from women end users and health care providers in South Africa and Zimbabwe.

Sikhanyisiwe Nkomo, Wanzirai Makoni, Mary Kate Shapley-Quinn, Ellen Luecke, Enough Mbatsane, Kgahlisho Manenzhe, Khatija Ahmed, Leah M Johnson, Imelda Mahaka, Ariane van der Straten

Abstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sikhanyisiwe NkomoPangaea Zimbabwe AIDS Trust, Harare, Zimbabwe.ORCID 0000-0003-2272-482X
Wanzirai MakoniPangaea Zimbabwe AIDS Trust, Harare, Zimbabwe.
Mary Kate Shapley-QuinnWomen's Global Health Imperative, RTI International, San Jose, California, United States of America.ORCID 0000-0001-9805-3132
Ellen LueckeWomen's Global Health Imperative, RTI International, San Jose, California, United States of America.ORCID 0000-0003-1509-5092
Enough MbatsaneSetshaba Research Centre, Soshanguve, South Africa.
Kgahlisho ManenzheSetshaba Research Centre, Soshanguve, South Africa.
Khatija AhmedSetshaba Research Centre, Soshanguve, South Africa.ORCID 0000-0003-0309-1641
Leah M JohnsonRTI International, Research Triangle Park, North Carolina, United States of America.
Imelda MahakaPangaea Zimbabwe AIDS Trust, Harare, Zimbabwe.
Ariane van der StratenASTRA Consulting, Kensington, California, United States of America.

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
NIMH NIH HHS P30 MH062246PEPFAR AID-OAA-A-17-00011
6 · The paper itself

Abstract

backgroundGiven the high rates of both HIV and unintended pregnancies in sub-Saharan Africa, the SCHIELD program aims to develop a multipurpose technology implant for HIV and pregnancy prevention. An end-user evaluation was undertaken with young women and health care providers to assess preferences for modifiable implant attributes to improve future adoption and rollout.

methodsFocus group discussions were conducted with potential women end users, and health care providers experienced in implant insertion or removal participated in in-depth interviews. All participants were recruited from Harare, Zimbabwe, or Soshanguve, South Africa. The purposively stratified sampled women were either implant experienced or implant naïve and were categorized into three groups: nulliparous, postpartum, or engaged in transactional sex. Topics covered included duration (six months to three years), biodegradability, removability, and independent rod retrievability (per indication). Data were analyzed using Dedoose software and summarized into emerging themes.

resultsParticipants identified three key areas that could facilitate rollout, uptake, and adherence of an implant for HIV and pregnancy prevention. First, discreetness was the most salient topic and was associated with implant characteristics such as anatomical location, flexibility, and biodegradability. Second, the ability to independently retrieve the HIV or pregnancy prevention component was preferred, as life circumstances may change and was favored by all participants, except for young women in Soshanguve. Third, there is a need for proper counseling, sensitization, provider training, and health campaigns to facilitate rollout of a 2-in-1 implant.

conclusionsA 2-in-1 implant was seen as highly desirable by most young women and health care providers. Participants discussed potential concerns and barriers to uptake of a biodegradable implant with dual HIV prevention and contraceptive properties, identifying key implant attributes that product developers can modify while still in preclinical stages.

Indexed as

HIV InfectionsPregnancy, UnplannedFemaleHealth PersonnelHumansPregnancyProspective StudiesSouth AfricaZimbabwe

Identifiers

PMID37195918
PMCPMC10191314

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.