Evidence map›Paper›PMID 37195561›Full record

ArticlePharmacological reports : PR2023

The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells.

Maciej Miliński, Monika Staś, Jakub Rok, Artur Beberok, Dorota Wrześniok

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maciej MilińskiFaculty of Chemistry, University of Opole, Oleska 48, 45-052, Opole, Poland. maciej.milinski@uni.opole.pl.ORCID http://orcid.org/0000-0001-5142-4186
Monika StaśFaculty of Chemistry, University of Opole, Oleska 48, 45-052, Opole, Poland.ORCID http://orcid.org/0000-0002-7854-0141
Jakub RokDepartment of Pharmaceutical Chemistry, School of Pharmacy With the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200, Sosnowiec, Poland.ORCID http://orcid.org/0000-0002-8260-4339
Artur BeberokDepartment of Pharmaceutical Chemistry, School of Pharmacy With the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200, Sosnowiec, Poland.ORCID http://orcid.org/0000-0003-2247-3004
Dorota WrześniokDepartment of Pharmaceutical Chemistry, School of Pharmacy With the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200, Sosnowiec, Poland.ORCID http://orcid.org/0000-0002-6918-3330
Medical University of Silesia · PLUniversity of Opole · PL

Funding

Śląski Uniwersytet Medyczny w Katowicach PCN-1-013/K/2/F
6 · The paper itself

Abstract

backgroundNon-steroidal anti-inflammatory drugs have been shown to inhibit the development of induced neoplasms. Our previous research demonstrated that the cytotoxicity of sulindac against melanoma cells is comparable to dacarbazine, the drug used in chemotherapy. The aim of this study was to investigate the mechanism of sulindac cytotoxicity on COLO 829 and C32 cell lines.

methodsThe influence of sundilac on the activity of selected enzymes of the antioxidant system (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and the content of hydrogen peroxide as well as the level of proteins initiating (p53, Bax) and inhibiting (Bcl-2) apoptosis were measured in melanoma cells.

resultsIn melanotic melanoma cells, sulindac increased the activity of SOD and the content of H

conclusionThe cytotoxic effect of sulindac in the COLO 829 cell line is connected to disturbed redox homeostasis by changing the activity of SOD, CAT, GPx, and level of H

Indexed as

HomeostasisMelanomaAntioxidantsApoptosis Regulatory ProteinsCatalaseCell Line, TumorGlutathione PeroxidaseHumansHydrogen PeroxideOxidation-ReductionSignal TransductionSulindacSuperoxide DismutaseAntioxidantsApoptosis Regulatory ProteinsCatalaseGlutathione PeroxidaseHydrogen PeroxideSulindacSuperoxide DismutaseAmelanotic melanomaCancerDacarbazineMelanotic melanomap53/Bax/Bcl-2 proteinsSulindac

Identifiers

PMID37195561
PMCPMC10374796
OpenAlexW4376872690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.