Evidence map›Paper›PMID 37195370›Full record

ArticleEJNMMI research2023

[

Muhummad Sohaib Nazir, Daniel Johnathan Hughes, Gitasha Chand, Kathryn Adamson, Jessica Johnson, Damion Bailey, Victoria Gibson, Hong Hoi Ting, Alexander R Lyon, Gary J R Cook and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04436406 (Measurement of PD-L1 Expression in Cancer to Monitor Treatment Response.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436406 naunknown statusnot on this map

Measurement of PD-L1 Expression in Cancer to Monitor Treatment Response.

TypeinterventionalSponsorGuy's and St Thomas' NHS Foundation TrustRan2020 to 2024Enrolled30ConditionsNon-small Cell Lung Cancer, MelanomaArms[99mTc]-NM-01 SPECT/CT
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Muhummad Sohaib Nazir *Department of Cardiovascular Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK. sohaib.nazir@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2749-1033
Daniel Johnathan Hughes *Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Gitasha ChandDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Kathryn AdamsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Jessica JohnsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Damion BaileyDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Victoria GibsonDepartment of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Hong Hoi TingNanomab Technology (UK) Limited, London, UK.
Alexander R LyonRoyal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
PECan study group
Guy's and St Thomas' NHS Foundation Trust · GBKing's College London · GB

Funding

National Institute for Health Research Health Protection Research Unit CL-2019-17-001
6 · The paper itself

Abstract

backgroundMyocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechanistic and predictive biomarker. The aim of this study was to determine non-invasive assessment of myocardial PD-L1 expression using [

methodsThoracic [

resultsMean LV

conclusionThis study is the first to report PD-L1 expression of the heart that can be quantified non-invasively without invasive myocardial biopsy, with high reliability and specificity. This technique can be applied to investigate myocardial PD-L1 expression in ICI-associated myocarditis and cardiomyopathies. Clinical trial registration PD-L1 Expression in Cancer (PECan) study (NCT04436406). https://clinicaltrials.gov/ct2/show/NCT04436406 June 18th, 2020.

Indexed as

Immune checkpoint inhibitorPD-L1 expressionSPECT-CT

Identifiers

PMID37195370
PMCPMC10192461
OpenAlexW4376873079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.