ArticleMicrobiology spectrum2023
The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria.
Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Hydrothermal regimes regulate microbiome patterns across vertical profile and their responses to alpine permafrost degradation.Nature communications · 2026Article
- Significant variability in virulence factors and antibiotic resistance of uropathogenic Escherichia coli strains may be counteracted by their susceptibility to lytic bacteriophages.Scientific reports · 2026Article
- Unmasking pathogen traits for chronic colonization in neurogenic bladder.Cell reports · 2026Article
- Nested mobile genetic elements mediating antimicrobial resistance genes mobility within and betweeniScience · 2026Article
- Virulence and Antimicrobial Resistance Traits ofAntibiotics (Basel, Switzerland) · 2026Article
- Prophage-mediated lysogenic conversion drives virulence evolution and genomic plasticity inMicrobiology spectrum · 2026Article
- Genomic characterization of multidrug-resistant Escherichia coli strains identified from patients with urinary tract infection in Egypt.Scientific reports · 2026Article
- Ecological context structures duplication and mobilization of antibiotic and metal resistance genes in bacteria.bioRxiv : the preprint server for biology · 2026Article
- Genomic insights into selected multidrug-resistant and ESBL-producing uropathogenicFrontiers in microbiology · 2026Article
- Age-dependent patterns of the gut microbiome, antibiotic resistome, and pathogenicity in captive koalas (Phascolarctos cinereus).Communications biology · 2025Article
- Transposon-plasmid nesting enables fast response to fluctuating environments.bioRxiv : the preprint server for biology · 2025Article
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- Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistantFrontiers in microbiology · 2025Article
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- Four New Sequence Types and Molecular Characteristics of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Genotypic and phenotypic characterisation of asymptomatic bacteriuria (ABU) isolates displaying bacterial interference against multi-drug resistant uropathogenic E. Coli.Archives of microbiology · 2024Article
- Competitive fitness of asymptomatic bacteriuriaInfection and immunity · 2024Article
- Evolution of the urinary microbiota in spinal cord injury patients with decubitus ulcer: A snapshot study.International wound journal · 2024Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Uropathogenic Escherichia coli (UPEC) is extremely diverse genotypically and phenotypically. Individual strains can variably carry diverse virulence factors, making it challenging to define a molecular signature for this pathotype. For many bacterial pathogens, mobile genetic elements (MGEs) constitute a major mechanism of virulence factor acquisition. For urinary E. coli, the total distribution of MGEs and their role in the acquisition of virulence factors is not well defined, including in the context of symptomatic infection versus asymptomatic bacteriuria (ASB). In this work, we characterized 151 isolates of E. coli, derived from patients with either urinary tract infection (UTI) or ASB. For both sets of E. coli, we catalogued the presence of plasmids, prophage, and transposons. We analyzed MGE sequences for the presence of virulence factors and antimicrobial resistance genes. These MGEs were associated with only ~4% of total virulence associated genes, while plasmids contributed to ~15% of antimicrobial resistance genes under consideration. Our analyses suggests that, across strains of E. coli, MGEs are not a prominent driver of urinary tract pathogenesis and symptomatic infection.
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