ArticleJournal of bacteriology2023
An Intestinal Bacillus velezensis Isolate Displays Broad-Spectrum Antibacterial Activity and Prevents Infection of Both Gram-Positive and Gram-Negative Pathogens
Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Photoperiod driven modulation of behavior, gut microbiota, and brain transcriptomics in zebrafish.Pflugers Archiv : European journal of physiology · 2026Article
- Identification and in-depth characterization of clinical isolates ofMicrobiology spectrum · 2026Article
- Isolation, evolution, and biological characterization of non-virulent and non-drug-resistant Escherichia coli from porcine intestine.Folia microbiologica · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- A Novel Protein Demonstrating Antibacterial Activity Against Multidrug-ResistantFoods (Basel, Switzerland) · 2025Article
- 3D imaging-driven assembly of multispecies biofilms with antagonistic activity against undesirable bacteria.ISME communications · 2025Article
- Complete genome sequence of aquaculture pond isolate,Microbiology resource announcements · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The increasing prevalence of drug-resistant bacteria has significantly diminished the effectiveness of antibiotics in clinical settings, leading to the emergence of untreatable bacterial infections. To address this public health challenge, the gut microbiome represents a promising source of novel antimicrobial therapeutics. In this study, we screened mouse intestinal isolates for growth inhibitory activity against the human enteric pathogen Vibrio cholerae and identified a strain of spore-forming Bacillus velezensis, named BVM7, that produced a potent antibiotic with activity against V. cholerae and a broad spectrum of enteric and opportunistic pathogens. Characterization of the antimicrobial compounds produced by BVM7 revealed that they were primarily secreted antimicrobial peptides (AMPs) produced during stationary-phase growth. Furthermore, our results showed that introducing either BVM7 vegetative cells or spores into mice precolonized with V. cholerae or Enterococcus faecalis significantly reduced the burden of infection. Interestingly, we also observed that BVM7 was sensitive to a group of
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Registered trials
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