ArticleEpilepsia2023
Multimodal nocturnal seizure detection in children with epilepsy: A prospective, multicenter, long-term, in-home trial.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03909984 (Promoting Implementation of Seizure Detection Devices in Epilepsy Care), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Promoting Implementation of Seizure Detection Devices in Epilepsy Care: the PROMISE Study
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- A multicenter, video-EEG-based validation of a multimodal wearable device for focal seizure detection in adults: The SeizeIT2 study.Epilepsia open · 2026Trial
- Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring.Annals of clinical and translational neurology · 2026Article
- Sounding the Alarm: Accuracy of Seizure Detection Devices.Epilepsy currents · 2026Article
- Holistic management of epilepsy in adults with intellectual development disorders.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Pulse-based photoplethysmography quality assessment improves wearable seizure detection performance.Epilepsia open · 2026Article
- Wearable Technologies for Clinical Assessment and Monitoring in Pediatric Neurodevelopmental Disorders : A Narrative Review.Journal of Korean Neurosurgical Society · 2026Article
- Sudden unexpected death in epilepsy (SUDEP): Risk management of pediatric patients with epilepsy.Epilepsia open · 2026Article
- How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?Epilepsia · 2025Article
- Autonomic biosignals, seizure detection, and forecasting.Epilepsia · 2025Review
- Users' perspectives and preferences on using wearables in epilepsy: A critical review.Epilepsia · 2025Review
- Deep learning-based detection of generalized convulsive seizures using a wrist-worn accelerometer.Epilepsia · 2025Article
- Detection of epileptic spasms using foundational AI and smartphone videos.NPJ digital medicine · 2025Article
- Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography.Scientific reports · 2025Article
- Innovating pediatric epilepsy: transforming diagnosis and treatment with AI.World journal of pediatrics : WJP · 2025Article
- Health State Utility Values in Children and Adolescents with Disabilities: A Systematic Review.Journal of pediatrics. Clinical practice · 2025Article
- Seizure Detection Devices.Journal of clinical medicine · 2025Review
- Artificial Intelligence in Pediatric Epilepsy Detection: Balancing Effectiveness With Ethical Considerations for Welfare.Health science reports · 2025Article
- A deep hybrid CSAE-GRU framework with two-stage balancing for automatic epileptic seizure detection using EEG-derived features.Frontiers in neuroscience · 2025Article
- Article
- Economic Perspective of the Use of Wearables in Health Care: A Systematic Review.Mayo Clinic proceedings. Digital health · 2024Review
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveThere is a pressing need for reliable automated seizure detection in epilepsy care. Performance evidence on ambulatory non-electroencephalography-based seizure detection devices is low, and evidence on their effect on caregiver's stress, sleep, and quality of life (QoL) is still lacking. We aimed to determine the performance of NightWatch, a wearable nocturnal seizure detection device, in children with epilepsy in the family home setting and to assess its impact on caregiver burden.
methodsWe conducted a phase 4, multicenter, prospective, video-controlled, in-home NightWatch implementation study (NCT03909984). We included children aged 4-16 years, with ≥1 weekly nocturnal major motor seizure, living at home. We compared a 2-month baseline period with a 2-month NightWatch intervention. The primary outcome was the detection performance of NightWatch for major motor seizures (focal to bilateral or generalized tonic-clonic [TC] seizures, focal to bilateral or generalized tonic seizures lasting >30 s, hyperkinetic seizures, and a remainder category of focal to bilateral or generalized clonic seizures and "TC-like" seizures). Secondary outcomes included caregivers' stress (Caregiver Strain Index [CSI]), sleep (Pittsburgh Quality of Sleep Index), and QoL (EuroQol five-dimension five-level scale).
resultsWe included 53 children (55% male, mean age = 9.7 ± 3.6 years, 68% learning disability) and analyzed 2310 nights (28 173 h), including 552 major motor seizures. Nineteen participants did not experience any episode of interest during the trial. The median detection sensitivity per participant was 100% (range = 46%-100%), and the median individual false alarm rate was .04 per hour (range = 0-.53). Caregiver's stress decreased significantly (mean total CSI score = 8.0 vs. 7.1, p = .032), whereas caregiver's sleep and QoL did not change significantly during the trial. SIGNIFICANCE: The NightWatch system demonstrated high sensitivity for detecting nocturnal major motor seizures in children in a family home setting and reduced caregiver stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.