ArticleHuman brain mapping2023
Brain-wide associations between white matter and age highlight the role of fornix microstructure in brain ageing.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Mapping and manipulating aged and senescent microglia.Nature aging · 2026Article
- Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.Nature aging · 2026Article
- Structural Brain Correlates of Poor Reading Comprehension.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Microstructural maturation of the adult mouse brain.Communications biology · 2025Article
- Multimodal predictors of disability progression and processing speed decline in relapsing-remitting multiple sclerosis.Scientific reports · 2025Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Unraveling Microstructural and Macrostructural Brain Age Dynamics in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Rate of brain aging associates with future executive function in Asian children and older adults.eLife · 2025Article
- Predicting brain age for veterans with traumatic brain injuries and healthy controls: an exploratory analysis.Frontiers in aging neuroscience · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- FreeSurfer version-shuffling can enhance brain age predictions.Neuroimage. Reports · 2024Article
- Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank.Biological psychiatry global open science · 2024Article
- Choir singing is associated with enhanced structural connectivity across the adult lifespan.Human brain mapping · 2024Article
- Brain asymmetries from mid- to late life and hemispheric brain age.Nature communications · 2024Article
- Associations between adiposity and white matter hyperintensities: Cross-sectional and longitudinal analyses of 34,653 participants.Human brain mapping · 2024Article
- Considerations on brain age predictions from repeatedly sampled data across time.Brain and behavior · 2023Article
- Brain-wide associations between white matter and age highlight the role of fornix microstructure in brain ageing.Human brain mapping · 2023Article
- Bio-psycho-social factors' associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants.Frontiers in psychology · 2023Article
- Unique information from common diffusion MRI models about white-matter differences across the human adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Mapping neurodegeneration with diffusion MRI: biomarkers, mechanisms, and clinical translation.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unveiling the details of white matter (WM) maturation throughout ageing is a fundamental question for understanding the ageing brain. In an extensive comparison of brain age predictions and age-associations of WM features from different diffusion approaches, we analyzed UK Biobank diffusion magnetic resonance imaging (dMRI) data across midlife and older age (N = 35,749, 44.6-82.8 years of age). Conventional and advanced dMRI approaches were consistent in predicting brain age. WM-age associations indicate a steady microstructure degeneration with increasing age from midlife to older ages. Brain age was estimated best when combining diffusion approaches, showing different aspects of WM contributing to brain age. Fornix was found as the central region for brain age predictions across diffusion approaches in complement to forceps minor as another important region. These regions exhibited a general pattern of positive associations with age for intra axonal water fractions, axial, radial diffusivities, and negative relationships with age for mean diffusivities, fractional anisotropy, kurtosis. We encourage the application of multiple dMRI approaches for detailed insights into WM, and the further investigation of fornix and forceps as potential biomarkers of brain age and ageing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.