SynthesisHuman brain mapping2023
Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.
Synthesis in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- Ancestral organisation and asymmetric circuit architecture of the habenula revealed in a basal ray-finned fish.Brain structure & function · 2026Article
- Habenula volume alterations in adults born very preterm.Scientific reports · 2026Article
- Habenular structural-functional dysconnectivity in bipolar disorder: evidence from multimodal imaging and transcriptomic integration.BMC psychiatry · 2026Article
- Article
- Surrogate GPR139 Agonists Reverse Short-Term Startle Habituation Impairment in Larval Zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development.Frontiers in cell and developmental biology · 2025Article
- Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism.General psychiatry · 2025Article
- Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri.Frontiers in human neuroscience · 2025Article
- Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.Nature communications · 2024Article
- Habenular volume changes after venlafaxine treatment in patients with major depression.Psychiatry and clinical neurosciences · 2024Article
- Segmentation and Volume Estimation of the Habenula Using Deep Learning in Patients With Depression.Biological psychiatry global open science · 2024Article
- The Neuroanatomy of the Habenular Complex and Its Role in the Regulation of Affective Behaviors.Journal of functional morphology and kinesiology · 2024Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Understanding the evolutionarily conserved feature of functional laterality in the habenula has been attracting attention due to its potential role in human cognition and neuropsychiatric disorders. Deciphering the structure of the human habenula remains to be challenging, which resulted in inconsistent findings for brain disorders. Here, we present a large-scale meta-analysis of the left-right differences in the habenular volume in the human brain to provide a clearer picture of the habenular asymmetry. We searched PubMed, Web of Science, and Google Scholar for articles that reported volume data of the bilateral habenula in the human brain, and assessed the left-right differences. We also assessed the potential effects of several moderating variables including the mean age of the participants, magnetic field strengths of the scanners and different disorders by using meta-regression and subgroup analysis. In total 52 datasets (N = 1427) were identified and showed significant heterogeneity in the left-right differences and the unilateral volume per se. Moderator analyses suggested that such heterogeneity was mainly due to different MRI scanners and segmentation approaches used. While inversed asymmetry patterns were suggested in patients with depression (leftward) and schizophrenia (rightward), no significant disorder-related differences relative to healthy controls were found in either the left-right asymmetry or the unilateral volume. This study provides useful data for future studies of brain imaging and methodological developments related to precision habenula measurements, and also helps to further understand potential roles of the habenula in various disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.