Evidence map›Paper›PMID 37194765›Full record

Observational studySao Paulo medical journal = Revista paulista de medicina2023

Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?

Mariana Dalbo Contrera Toro, Erica Ortiz, Fernando Augusto Lima Marson, Laíza Mohana Pinheiro, Adyléia Aparecida Dalbo Contrera Toro, José Dirceu Ribeiro, Eulália Sakano

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sao Paulo medical journal = Revista paulista de medicina, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariana Dalbo Contrera ToroMD, MSc. PhD Student, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0002-5294-3698
Erica OrtizMD, PhD. Physician, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0003-4381-5149
Fernando Augusto Lima MarsonMD, PhD. Physician, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil; Researcher, Laboratory of Medical Genetics and Genome Medicine, Department of Medical Genetics, Faculty of Medical Sciences, UNICAMP, Campinas (SP), Brazil; Professor, Laboratory of Human and Medical Genetics, Universidade São Francisco, Bragança Paulista (SP), Brazil.ORCID 0000-0003-4955-4234
Laíza Mohana PinheiroMD. Physician, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0001-6352-5507
Adyléia Aparecida Dalbo Contrera ToroMD, PhD. Adjunct Professor, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0001-5777-1146
José Dirceu RibeiroMD, PhD. Pediatric Pulmonologist and Full Professor, Department of Pediatrics, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0002-3387-5642
Eulália SakanoMD, PhD. Adjunct Professor, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.ORCID 0000-0002-5963-912X
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD.

objectivesThis study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group. DESIGN AND

settingAn observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021.

methodPatients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy.

resultsThirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients.

conclusionThe saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD.

Indexed as

Kartagener SyndromePneumoniaCross-Sectional StudiesHumansMicroscopy, Electron, TransmissionSaccharinSaccharin

Identifiers

PMID37194765
PMCPMC10181835
OpenAlexW4376871090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.