Trial reportPediatric blood & cancer2023
Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.
Trial report in Pediatric blood & cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04084067 (Indocyanine Green), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Indocyanine Green (ICG) Guided Tumor Resection
Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- CT-guided methylene blue staining to facilitate thoracoscopic resection of intermediate-to-deep pulmonary metastases in pediatric patients.Pediatric surgery international · 2026Article
- Thermal ablation of lung metastases in children: what every paediatric radiologist should know.Pediatric radiology · 2026Review
- Dual-coil localization with intentional pneumothorax for pulmonary nodule resection in pediatric patients: a novel technical approach.Pediatric radiology · 2026Article
- Imaging and characterization of pulmonary nodules in children with solid tumors: what makes a pulmonary nodule a metastasis?Pediatric radiology · 2026Review
- Caregivers' perceptions of fluorescence-guided surgery (FGS) in pediatric oncology: a questionnaire-based study.Pediatric surgery international · 2026Article
- Lighting the path: a narrative review of non-molecular intraoperative lung imaging modalities.Journal of thoracic disease · 2026Review
- International Society of Paediatric Surgical Oncology (IPSO) Minimally Invasive Surgery (MIS) Guidelines.Ecancermedicalscience · 2026Article
- Fluorescence-Guided Surgery in Pediatric Oncology: Current Practice and Future Directions.Cancers · 2025Review
- Next-Generation Imaging Techniques for Surgical Guidance in Pediatric Tumors.Annals of surgical oncology · 2025Review
- Advances in Fluorescent Adjuncts in Pediatric Surgery: A Comprehensive Review of Applications of Indocyanine Green Across Surgical Specialties.Children (Basel, Switzerland) · 2025Review
- Hepatoblastoma.Nature reviews. Disease primers · 2025Review
- Identifying Molecular Probes for Fluorescence-Guided Surgery in Neuroblastoma: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Advancing Pediatric Surgery with Indocyanine Green (ICG) Fluorescence Imaging: A Comprehensive Review.Children (Basel, Switzerland) · 2025Review
- New technologies in minimally invasive surgery in childhood cancer surgery.Ecancermedicalscience · 2025Article
- Role of minimally invasive surgery in paediatric pulmonary metastatic disease.Ecancermedicalscience · 2025Article
- Children's Oncology Group's 2023 blueprint for research: Surgery.Pediatric blood & cancer · 2024Article
- Indocyanine Green (ICG) Fluorescence-Assisted Open Surgery Using the RubinaChildren (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundClearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can be challenging. Therefore, an intraoperative tool that localizes pulmonary metastases is needed to improve diagnostic and therapeutic resections. Indocyanine green (ICG) real-time fluorescence imaging is used for this purpose in adult solid tumors, but its utility in pediatric solid tumors has not been determined.
methodsA single-center, open-label, nonrandomized, prospective clinical trial (NCT04084067) was conducted to assess the ability of ICG to localize pulmonary metastases of pediatric solid tumors. Patients with pulmonary lesions who required resection, either for therapeutic or diagnostic intent, were included. Patients received a 15-minute intravenous infusion of ICG (1.5 mg/kg), and pulmonary metastasectomy was performed the following day. A near-infrared spectroscopy iridium system was optimized to detect ICG, and all procedures were photo-documented and recorded.
resultsICG-guided pulmonary metastasectomies were performed in 12 patients (median age: 10.5 years). A total of 79 nodules were visualized, 13 of which were not detected by preoperative imaging. Histologic examination confirmed the following histologies: hepatoblastoma (n = 3), osteosarcoma (n = 2), and one each of rhabdomyosarcoma, Ewing sarcoma, inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, and papillary thyroid carcinoma. ICG guidance failed to localize pulmonary metastases in five (42%) patients who had inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, or papillary thyroid carcinoma.
conclusionsICG-guided identification of pulmonary nodules is not feasible for all pediatric solid tumors. However, it may localize most metastatic hepatic tumors and high-grade sarcomas in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.