Evidence map›Paper›PMID 37194290›Full record

ArticleJournal of biomolecular structure & dynamics2024

Modeling the Annexin A1-S100A11 heterotetramer: a molecular dynamics investigation of structure and correlated motion.

Wesley Sanchez, Samuel Lindsay, Yumin Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wesley SanchezDepartment of Chemistry, East Carolina University, Greenville, NC, USA.
Samuel LindsayDepartment of Chemistry, East Carolina University, Greenville, NC, USA.
Yumin LiDepartment of Chemistry, East Carolina University, Greenville, NC, USA.
East Carolina University · US

Funding

Simulation of Interactions between S100A(10/11)-Annexin A2 Tetramers and Membrane to Develop Efficient Binding LigandsR15GM131324 · NIGMS · EAST CAROLINA UNIVERSITY · PI LI, YUMIN · 2019 to 2019
$416k
NIGMS NIH HHS R15 GM131324
6 · The paper itself

Abstract

Annexin A1 (A1) has been shown to form a tetrameric complex (A1t) with S100A11 which is implicated in calcium homeostasis and EGFR pathways. In this work, a full-length model of the A1t was generated for the first time. Multiple molecular dynamics simulations were performed on the complete A1t model for several hundred nanoseconds each to assess the structure and dynamics of A1t. These simulations yielded three structures for the A1 N-terminus (ND) which were identified

Indexed as

Annexin A1Annexin A2SulfonamidesMolecular Dynamics SimulationS100 ProteinsAnnexin A1Annexin A2S100 ProteinsSulfonamidesW 12Annexin-S100 heterotetramerCross correlationMolecular dynamicsPCA analysis

Identifiers

PMID37194290
PMCPMC10654263
OpenAlexW4376871463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.