Observational studyThe Journal of international medical research2023
Relationships of serum VILIP-1, NSE, and ADP levels with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia: a retrospective, observational study.
Observational study in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Pooled it
- Variations in S-100Β and Neuron-Specific Enolase Levels During Functional Endoscopic Sinus Surgery Under Moderately Controlled Hypotension Using Four Distinct Anesthetic Protocols: A Randomized Controlled Study.Medicina (Kaunas, Lithuania) · 2026Trial
- Risk Assessment of Serum Biomarkers with Perioperative Neurocognitive Dysfunction in Elderly Patients Undergoing Thoracic Surgery: A Prospective Cohort Study.Cellular and molecular neurobiology · 2025Article
- Neuron-Specific Enolase and S100B as Biomarkers of Ischemic Brain Injury During Surgery.Clinics and practice · 2025Review
- Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory-Locomotor Behavior in Aged Diabetic Rats.Journal of aging research · 2025Article
- Research progress of neuron-specific enolase in cognitive disorder: a mini review.Frontiers in human neuroscience · 2024Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationships of serum visinin-like protein-1 (VILIP-1), neuron-specific enolase (NSE), and adiponectin (ADP) levels with postoperative cognitive dysfunction (POCD) in elderly patients undergoing general anesthesia and provide a reference for the prevention and treatment of POCD.
methodsIn this retrospective, observational study, 162 elderly patients who underwent general anesthesia were divided into POCD and non-POCD groups according to whether POCD occurred with 24 hours after surgery. Serum VILIP-1, NSE, and ADP levels were measured.
resultsImmediately after and 24 hours after surgery, serum VILIP-1 and NSE levels were significantly higher in the POCD group than in the non-POCD group, whereas serum ADP levels were significantly lower in the POCD group. Mini-mental state examination (MMSE) scores significantly differed between the two groups. At 24 hours after surgery, serum VILIP-1 and NSE levels were negatively correlated with MMSE scores in the POCD group, whereas serum ADP levels were positively correlated with MMSE scores in this group.
conclusionIncreased serum VILIP-1 and NSE levels and decreased serum ADP levels could be involved in the pathophysiology of POCD in elderly patients after general anesthesia. These serum markers could be used as indicators of POCD in elderly patients undergoing general anesthesia.
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