ArticleBiotechnology for biofuels and bioproducts2023
Upgrading dilute ethanol to odd-chain carboxylic acids by a synthetic co-culture of Anaerotignum neopropionicum and Clostridium kluyveri.
Article in Biotechnology for biofuels and bioproducts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Synthetic Microbial Cocultivation for Targeted Production of Odd-Chain Carboxylates and Alcohols from Carbon Monoxide.Environmental science & technology · 2025Article
- Implementation of aComputational and structural biotechnology journal · 2025Article
- Microbial Electrochemical Technologies: Sustainable Solutions for Addressing Environmental Challenges.Advances in biochemical engineering/biotechnology · 2025Review
- Microbial conversion of ethanol to high-value products: progress and challenges.Biotechnology for biofuels and bioproducts · 2024Review
- Effect of pH and medium composition on chain elongation withFrontiers in microbiology · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDilute ethanol streams generated during fermentation of biomass or syngas can be used as feedstocks for the production of higher value products. In this study, we describe a novel synthetic microbial co-culture that can effectively upgrade dilute ethanol streams to odd-chain carboxylic acids (OCCAs), specifically valerate and heptanoate. The co-culture consists of two strict anaerobic microorganisms: Anaerotignum neopropionicum, a propionigenic bacterium that ferments ethanol, and Clostridium kluyveri, well-known for its chain-elongating metabolism. In this co-culture, A. neopropionicum grows on ethanol and CO
resultsA co-culture of A. neopropionicum and C. kluyveri was established in serum bottles with 50 mM ethanol, leading to the production of valerate (5.4 ± 0.1 mM) as main product of ethanol-driven chain elongation. In a continuous bioreactor supplied with 3.1 g ethanol L
conclusionsThis study highlights the potential of synthetic co-cultivation in chain elongation processes to target the production of OCCAs. Furthermore, our findings shed light on to the metabolism of odd-chain elongation by C. kluyveri.
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