Evidence map›Paper›PMID 37194021›Full record

ArticleBMC infectious diseases2023

Risk factors for SARS-CoV-2 seropositivity in a health care worker population during the early pandemic.

Sebastian D Schubl, Cesar Figueroa, Anton M Palma, Rafael R de Assis, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Danielle Brabender, Sina Hosseinian, Ariana Naaseh and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 3 institutions in 1 country.

Sebastian D SchublDepartment of Surgery, School of Medicine, University of California Irvine, Irvine, CA, USA.
Cesar FigueroaDepartment of Surgery, School of Medicine, University of California Irvine, Irvine, CA, USA.
Anton M PalmaInstitute for Clinical and Translational Sciences, University of California Irvine, Irvine, CA, USA.
Rafael R de AssisDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Aarti JainDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Rie NakajimaDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Algimantas JasinskasDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Danielle BrabenderDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sina HosseinianSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Ariana NaasehSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Oscar Hernandez DominguezSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Ava RungeSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Shannon SkochkoSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Justine ChinnSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Adam J KelseyDepartment of Pharmaceutical Sciences, School of Medicine, University of California Irvine, Irvine, CA, USA.
Kieu T LaiDepartment of Pharmaceutical Sciences, School of Medicine, University of California Irvine, Irvine, CA, USA.
Weian ZhaoDepartment of Pharmaceutical Sciences, School of Medicine, University of California Irvine, Irvine, CA, USA.
Peter HorvathInstitute for Clinical and Translational Sciences, University of California Irvine, Irvine, CA, USA.
Delia TifreaDepartment of Pathology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Areg GrigorianDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Abran GonzalesDepartment of Surgery, School of Medicine, University of California Irvine, Irvine, CA, USA.
Suzanne AdelsohnDepartment of Pathology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Frank ZaldivarInstitute for Clinical and Translational Sciences, University of California Irvine, Irvine, CA, USA.
Robert EdwardsDepartment of Pathology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Alpesh N AminDepartment of Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA.
Michael J StamosSchool of Medicine, University of California Irvine, Irvine, CA, USA.
Philip S BarieDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Philip L FelgnerDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.
Saahir KhanDivision of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, 1520 San Pablo St., Los Angeles, CA, 90033, USA. saahirkh@usc.edu.
University of California, Irvine · USUniversity of Southern California · USCornell University · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Marian L Waterman · 1994 to 2026
$57.9M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NCATS NIH HHS KL2 TR001416NCATS NIH HHS KL2 TR001416, UL1 TR001414NCATS NIH HHS UL1 TR001414NCI NIH HHS P30 CA062203NCI NIH HHS P30CA062203
6 · The paper itself

Abstract

backgroundWhile others have reported severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2) seroprevalence studies in health care workers (HCWs), we leverage the use of a highly sensitive coronavirus antigen microarray to identify a group of seropositive health care workers who were missed by daily symptom screening that was instituted prior to any epidemiologically significant local outbreak. Given that most health care facilities rely on daily symptom screening as the primary method to identify SARS-CoV-2 among health care workers, here, we aim to determine how demographic, occupational, and clinical variables influence SARS-CoV-2 seropositivity among health care workers.

methodsWe designed a cross-sectional survey of HCWs for SARS-CoV-2 seropositivity conducted from May 15th to June 30th 2020 at a 418-bed academic hospital in Orange County, California. From an eligible population of 5,349 HCWs, study participants were recruited in two ways: an open cohort, and a targeted cohort. The open cohort was open to anyone, whereas the targeted cohort that recruited HCWs previously screened for COVID-19 or work in high-risk units. A total of 1,557 HCWs completed the survey and provided specimens, including 1,044 in the open cohort and 513 in the targeted cohort. Demographic, occupational, and clinical variables were surveyed electronically. SARS-CoV-2 seropositivity was assessed using a coronavirus antigen microarray (CoVAM), which measures antibodies against eleven viral antigens to identify prior infection with 98% specificity and 93% sensitivity.

resultsAmong tested HCWs (n = 1,557), SARS-CoV-2 seropositivity was 10.8%, and risk factors included male gender (OR 1.48, 95% CI 1.05-2.06), exposure to COVID-19 outside of work (2.29, 1.14-4.29), working in food or environmental services (4.85, 1.51-14.85), and working in COVID-19 units (ICU: 2.28, 1.29-3.96; ward: 1.59, 1.01-2.48). Amongst 1,103 HCWs not previously screened, seropositivity was 8.0%, and additional risk factors included younger age (1.57, 1.00-2.45) and working in administration (2.69, 1.10-7.10).

conclusionSARS-CoV-2 seropositivity is significantly higher than reported case counts even among HCWs who are meticulously screened. Seropositive HCWs missed by screening were more likely to be younger, work outside direct patient care, or have exposure outside of work.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralCross-Sectional StudiesHealth PersonnelHumansMalePandemicsSeroepidemiologic StudiesAntibodies, ViralHealthcare workersRisk analysisSARS-CoV-2Serology

Identifiers

PMID37194021
PMCPMC10186297
OpenAlexW4376643893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.